2. Membrane Transporter/Ion Channel
  3. Potassium Channel
  4. SK3 Channel-IN-1

SK3 Channel-IN-1 (compound 7a) 是一种有效的 SK3 通道调节剂。SK3 Channel-IN-1 对乳腺癌细胞 MDA-MB-435 的迁移具有有效的作用，而对其他细胞系的细胞毒性较低。SK3 Channel-IN-1 可调节肿瘤中离子通道的活性。

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SK3 Channel-IN-1 Chemical Structure

SK3 Channel-IN-1 Chemical Structure

CAS No. : 2396571-04-1

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SK3 Channel-IN-1 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

SK3 Channel-IN-1 (compound 7a) is a potent and specific SK3 channel modulator. SK3 Channel-IN-1 has efficient effect on breast cancer MDA-MB-435 cell migration while exhibiting low cytotoxicity in other cell lines. SK3 Channel-IN-1 can modulate ion channels’activity in cancer[1].

IC50 & Target

IC50: 16 μM in CaCo-2[1]
细胞效力
(Cellular Effect)
Cell Line Type Value Description References
Caco-2 IC50
16 μM
Compound: 7a
Toxicity in human Caco-2 cells assessed as reduction in cell number after 48 hrs by Hoechst 33342 staining based assay
Toxicity in human Caco-2 cells assessed as reduction in cell number after 48 hrs by Hoechst 33342 staining based assay
[PMID: 31753515]
Fibroblast IC50
> 25 μM
Compound: 7a
Toxicity in human skin fibroblasts assessed as reduction in cell number after 48 hrs by Hoechst 33342 staining based assay
Toxicity in human skin fibroblasts assessed as reduction in cell number after 48 hrs by Hoechst 33342 staining based assay
[PMID: 31753515]
HCT-116 IC50
> 25 μM
Compound: 7a
Toxicity in human HCT-116 cells assessed as reduction in cell number after 48 hrs by Hoechst 33342 staining based assay
Toxicity in human HCT-116 cells assessed as reduction in cell number after 48 hrs by Hoechst 33342 staining based assay
[PMID: 31753515]
Huh-7 IC50
> 25 μM
Compound: 7a
Toxicity in human Huh-7 cells assessed as reduction in cell number after 48 hrs by Hoechst 33342 staining based assay
Toxicity in human Huh-7 cells assessed as reduction in cell number after 48 hrs by Hoechst 33342 staining based assay
[PMID: 31753515]
MCF7 IC50
> 25 μM
Compound: 7a
Toxicity in human MCF7 cells assessed as reduction in cell number after 48 hrs by Hoechst 33342 staining based assay
Toxicity in human MCF7 cells assessed as reduction in cell number after 48 hrs by Hoechst 33342 staining based assay
[PMID: 31753515]
MDA-MB-231 IC50
> 25 μM
Compound: 7a
Toxicity in human MDA-MB-231 cells assessed as reduction in cell number after 48 hrs by Hoechst 33342 staining based assay
Toxicity in human MDA-MB-231 cells assessed as reduction in cell number after 48 hrs by Hoechst 33342 staining based assay
[PMID: 31753515]
NCI-H727 IC50
> 25 μM
Compound: 7a
Toxicity in human NCI-H727 cells assessed as reduction in cell number after 48 hrs by Hoechst 33342 staining based assay
Toxicity in human NCI-H727 cells assessed as reduction in cell number after 48 hrs by Hoechst 33342 staining based assay
[PMID: 31753515]
PC-3 IC50
> 25 μM
Compound: 7a
Toxicity in human PC-3 cells assessed as reduction in cell number after 48 hrs by Hoechst 33342 staining based assay
Toxicity in human PC-3 cells assessed as reduction in cell number after 48 hrs by Hoechst 33342 staining based assay
[PMID: 31753515]
分子量

379.66

Formula

C25H49NO
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

SK3 Channel-IN-1 相关分类

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  • 稀释计算器

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

SK3 Channel-IN-12396571-04-1Potassium ChannelKcsABreast cancerCell migrationIon channelAnticancerMDA-MB-435?cellsInhibitorinhibitorinhibit

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