1. Apoptosis
  2. Apoptosis
  3. SLC7A11-IN-1

SLC7A11-IN-1 是一种有效的SLC7A11 抑制剂。SLC7A11-IN-1 显示出抗增殖活性。SLC7A11-IN-1 抑制细胞侵袭和转移。SLC7A11-IN-1 诱导细胞凋亡 (Apoptosis) 和细胞周期停滞在 S 期。SLC7A11-IN-1 具有抗肿瘤活性。

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SLC7A11-IN-1 Chemical Structure

SLC7A11-IN-1 Chemical Structure

CAS No. : 3049302-90-8

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规格 价格 是否有货 数量
10 mM * 1 mL in DMSO ¥12716
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1 mg ¥3480
In-stock
5 mg 现货 询价
10 mg   询价  
50 mg   询价  

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Customer Review

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

SLC7A11-IN-1 is a potent solute carrier family 7 member 11 (SLC7A11, xCT) inhibitor. SLC7A11-IN-1 shows antiproliferative activity. SLC7A11-IN-1 inhibits cell invasion and metastasis. SLC7A11-IN-1 induces Apoptosis and cell cycle arrest at S-phase. SLC7A11-IN-1 shows anti-tumor activity[1].

IC50 & Target

SLC7A11[1]

体外研究
(In Vitro)

SLC7A11-IN-1 (compound 2; 0-100 µM; 72 h) 显示出抗增殖活性,对于 HCT-116, MDA-MB-231, MCF-7, HepG2, LO2 细胞的 IC50 值分别为 0.03、0.11、0.18、0.17、0.27 µM[1]
SLC7A11-IN-1 (0.5 µM; 24 h) 抑制 HCT-116 细胞的侵袭和转移[1]
SLC7A11-IN-1 (0.5 µM; 24 h) 诱导细胞凋亡和细胞周期停滞在 S 期[1]
SLC7A11-IN-1明显降低细胞内 GSH 含量,显着增强活性氧 (ROS) 的表达[1]
SLC7A11-IN-1 (1 µM; 15 h) 显著诱导 HCT-116 细胞的 DNA 损伤和相关蛋白表达[1]

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Cycle Analysis[1]

Cell Line: HCT-116 cells
Concentration: 0.5 µM
Incubation Time: 24 h
Result: Induced cell apoptosis and cell cycle arrest at S-phase with the S-phase proportion of 55.79%.

Western Blot Analysis[1]

Cell Line: HCT-116 cells
Concentration: 1 µM
Incubation Time: 15 h
Result: Increased the expression of p53, Bax, p-Akt, VEGFA and HIF1-α proteins, decreased the expression of Bcl-2, xCT protein level.
体内研究
(In Vivo)

SLC7A11-IN-1 (2 mg/kg;尾静脉注射; 每三天一次,连续3次) 抑制小鼠肿瘤的生长[1]

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: male BALB/c mice (CT26 tumor models)[1]
Dosage: 2 mg/kg
Administration: I.v.; once every three days, for consecutive 3 times
Result: Suppressed the growth of tumor by 60.7%.
分子量

664.35

Formula

C13H17Cl2F3N4O5PtS

CAS 号
性状

固体

颜色

White to off-white

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
溶解性数据
细胞实验: 

DMSO 中的溶解度 : ≥ 20 mg/mL (30.10 mM; 吸湿的 DMSO 对产品的溶解度有显著影响,请使用新开封的 DMSO)

* "≥" means soluble, but saturation unknown.

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 1.5052 mL 7.5262 mL 15.0523 mL
5 mM 0.3010 mL 1.5052 mL 3.0105 mL
查看完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;一旦配成溶液,请分装保存,避免反复冻融造成的产品失效
储备液的保存方式和期限:-80°C, 6 months; -20°C, 1 month。-80°C储存时,请在6个月内使用,-20°C储存时,请在1个月内使用。

  • 摩尔计算器

  • 稀释计算器

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量
=
浓度
×
体积
×
分子量 *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start)

C1

×
体积 (start)

V1

=
浓度 (final)

C2

×
体积 (final)

V2

动物溶解方案计算器
请输入动物实验的基本信息:

给药剂量

mg/kg

动物的平均体重

g

每只动物的给药体积

μL

动物数量

由于实验过程有损耗,建议您多配一只动物的量
计算结果
工作液所需浓度 : mg/mL
纯度 & 产品资料

纯度: 95.93%

参考文献

完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;一旦配成溶液,请分装保存,避免反复冻融造成的产品失效
储备液的保存方式和期限:-80°C, 6 months; -20°C, 1 month。-80°C储存时,请在6个月内使用,-20°C储存时,请在1个月内使用。

可选溶剂 浓度 溶剂体积 质量 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 1.5052 mL 7.5262 mL 15.0523 mL 37.6308 mL
5 mM 0.3010 mL 1.5052 mL 3.0105 mL 7.5262 mL
10 mM 0.1505 mL 0.7526 mL 1.5052 mL 3.7631 mL
15 mM 0.1003 mL 0.5017 mL 1.0035 mL 2.5087 mL
20 mM 0.0753 mL 0.3763 mL 0.7526 mL 1.8815 mL
25 mM 0.0602 mL 0.3010 mL 0.6021 mL 1.5052 mL
30 mM 0.0502 mL 0.2509 mL 0.5017 mL 1.2544 mL
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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产品名称:
SLC7A11-IN-1
目录号:
HY-149979
需求量: