2. Cell Cycle/DNA Damage Epigenetics
  3. Aurora Kinase
  4. SNS-314

SNS-314 是一种有效的选择性极光激酶 (aurora) 抑制剂，对极光激酶 A，B，C 的IC50 值分别为 9，31 和 6 nM。

在相同的摩尔浓度下，化合物盐形式与游离形式有相同的生物活性，但盐形式 SNS-314 mesylate 通常具有更好的水溶性和稳定性。

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SNS-314 Chemical Structure

SNS-314 Chemical Structure

CAS No. : 1057249-41-8

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规格 是否有货
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SNS-314 的其他形式现货产品:

Customer Review

Other Forms of SNS-314:

SNS-314 相关抗体

Top Publications Citing Use of Products

查看 Aurora Kinase 亚型特异性产品:

查看所有亚型
Aurora Kinase Aurora A Aurora B Aurora C

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

SNS-314 is a potent and selective aurora kinase inhibitor with IC50s of 9, 31, and 6 nM for aurora A, B and C, respectively[1].

IC50 & Target[1]

Aurora A

9 nM (IC50)

Aurora B

31 nM (IC50)

Aurora C

6 nM (IC50)

体外研究
(In Vitro)

SNS-314 blocks proliferation in a broad panel of tumor cell lines (HCT116, A2780, PC-3, HeLa, MDA-MB-231, H-1299, and HT29) with IC50 values ranging from 1.8 nM in A2780 ovarian cancer cells to 24 nM in HT29 colon cancer cells[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

SNS-314 相关抗体:
体内研究
(In Vivo)

In the HCT116 human colon cancer xenograft model, administration of 50 and 100 mg/kg SNS-314 leads to dose-dependent inhibition of histone H3 phosphorylation for at least 10 h. SNS-314 shows significant tumor growth inhibition in a dose dependent manner under a variety of dosing schedules including weekly, bi-weekly, and 5 days on/9 days off[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
Clinical Trial
分子量

430.93

Formula

C18H15ClN6OS2
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

SNS-314 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

SNS-3141057249-41-8SNS314SNS 314Aurora KinaseHCT116A2780PC-3HeLaMDA-MB-231H-1299HT29ovarian cancer cellInhibitorinhibitorinhibit

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产品名称：
SNS-314
目录号：
HY-108344
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