2. Cell Cycle/DNA Damage Epigenetics Autophagy Apoptosis Metabolic Enzyme/Protease
  3. HDAC Autophagy Apoptosis Endogenous Metabolite
  4. Sodium butyrate

Sodium butyrate  (Synonyms: 丁酸钠; Butanoic acid sodium; Butyric acid sodium)

目录号: HY-B0350A 纯度: ≥98.0%
COA 产品使用指南

摩尔计算器

Sodium Butyrate (Butanoic acid sodium salt) 是一种 HDAC 抑制剂，具有抗肿瘤活。

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Sodium butyrate Chemical Structure

Sodium butyrate Chemical Structure

CAS No. : 156-54-7

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Other Forms of Sodium butyrate:

Sodium butyrate 相关抗体

Top Publications Citing Use of Products

    Sodium butyrate purchased from MCE. Usage Cited in: Neurobiol Dis. 2017 Dec 14;111:12-25.  [Abstract]

    Cdc42-Rac1 activation mediates the effect of SB on microglial process elongation. Representative images showing the activation effect of Cdc42 and Rac1 by Sodium butyrate (SB) (5 mM) at different time points (5, 10 min) in primary cultured microglia.

    查看 HDAC 亚型特异性产品:

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    HDAC HDAC1 HDAC2 HDAC3 HDAC4 HDAC5 HDAC6 HDAC7 HDAC8 HDAC9 HDAC10 HDAC11 HD1 HD2

    • 生物活性

    • 实验参考方法

    • 纯度 & 产品资料

    • 参考文献

    生物活性

    Sodium Butyrate (sodium butanoate) is an inhibitor of HDAC, possessing anti-tumor activity[1][2][3][4][5].

    IC50 & Target[2]

    HDAC

     

    Human Endogenous Metabolite

     

    Microbial Metabolite

     

    细胞效力
    (Cellular Effect)
    Cell Line Type Value Description References
    Erythrocyte CC50
    222 μM
    Compound: NaB
    Cytotoxicity against human erythrocytes assessed as cell viability after 3 days alamar blue assay
    Cytotoxicity against human erythrocytes assessed as cell viability after 3 days alamar blue assay
    		[PMID: 33109398]
    HeLa IC50
    0.8 mM
    Compound: Sodium butyrate
    Inhibition of HDAC in human Hela cells nuclear extracts by fluorimetric assay
    Inhibition of HDAC in human Hela cells nuclear extracts by fluorimetric assay
    		[PMID: 19520580]
    HUVEC IC50
    1 mM
    Compound: sodium butyrate
    Inhibition of LPS-induced tissue factor activity in HUVEC preincubated for 4 hrs assessed after 4 hrs of LPS challenge by one stage clotting assay
    Inhibition of LPS-induced tissue factor activity in HUVEC preincubated for 4 hrs assessed after 4 hrs of LPS challenge by one stage clotting assay
    		[PMID: 17675290]
    HUVEC IC50
    2 mM
    Compound: sodium butyrate
    Inhibition of TNF-alpha-induced tissue factor activity in HUVEC preincubated for 4 hrs assessed after 4 hrs of TNFalpha challenge by one stage clotting assay
    Inhibition of TNF-alpha-induced tissue factor activity in HUVEC preincubated for 4 hrs assessed after 4 hrs of TNFalpha challenge by one stage clotting assay
    		[PMID: 17675290]
    MDA-MB-231 GI50
    > 1000 μM
    Compound: BA, sodium butyrate
    Growth inhibition of human MDA-MB-231 cells after 5 days by MTT assay
    Growth inhibition of human MDA-MB-231 cells after 5 days by MTT assay
    		[PMID: 18543902]
    PC-3 GI50
    72.44 μM
    Compound: BA, sodium butyrate
    Growth inhibition of human PC3 cells after 5 days by MTT assay
    Growth inhibition of human PC3 cells after 5 days by MTT assay
    		[PMID: 18543902]
    体外研究
    (In Vitro)

    Sodium Butyrate 可诱导鼻咽癌细胞的形态变化、抑制细胞增殖并削弱细胞活力。Sodium Butyrate (1、5、10 mM) 对鼻咽癌细胞具有细胞毒性，在 5-8F 和 6-10B 细胞中均诱导剂量和时间依赖性的细胞活力下降。Sodium Butyrate 通过激活线粒体凋亡轴诱导鼻咽癌细胞凋亡。此外，SOCE 抑制和 CRAC 通道破坏可减弱Sodium Butyrate 诱导的细胞凋亡[1]。
    Sodium Butyrate 显著降低细胞活力，同时降低 p-mTOR 和 PCNA 蛋白水平。Sodium Butyrate 以剂量依赖性方式诱导细胞周期停滞在 G0/G1 期，并减少 S 期细胞数量。此外，较高浓度的 Sodium Butyrate (1、5、10 mM) 可增加 p21、p27 和促凋亡 bak 基因的相对表达以及 p21Waf1/Cip1、p27Kip1、cyclinD3、CDK4 和 Cleave-caspase3 的蛋白水平，而 5 和 10 mM 丁酸盐可降低 cyclinD1 和 CDK6 的水平[3]。

    MCE has not independently confirmed the accuracy of these methods. They are for reference only.

    Sodium butyrate 相关抗体:
    体内研究
    (In Vivo)

    与未治疗的动物相比，HI 后立即给予丁酸钠 (300 mg/kg，皮下) 可提供几乎完全的神经保护。给予丁酸钠会导致同侧小胶质细胞数量增加至接受载体治疗的动物的 150%。丁酸钠促进新生儿缺氧缺血后小胶质细胞从 M1 型极化为 M2 型表型[2]。丁酸钠 (300 mg/kg，皮下) 与 AK-7 (20 mg/kg，腹腔注射) 组合可显著缓解小鼠探索新物体时间的减少，改善小鼠齿状回中 Ki67 阳性细胞和 DCX 免疫反应性神经母细胞数量的减少。此外，丁酸钠可逆转 SIRT2 相关的年龄表型[4]。

    MCE has not independently confirmed the accuracy of these methods. They are for reference only.
    分子量

    110.09

    Formula

    C4H7NaO2
    CAS 号
    性状

    固体

    颜色

    White to off-white

    中文名称

    丁酸钠
    运输条件

    Room temperature in continental US; may vary elsewhere.
    储存方式

    4°C, sealed storage, away from moisture

    *In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

    溶解性数据
    细胞实验： 

    H2O 中的溶解度 : 100 mg/mL (908.36 mM; 超声助溶)

    配制储备液
    浓度 溶剂体积 质量 1 mg 5 mg 10 mg
    1 mM 9.0836 mL 45.4182 mL 90.8364 mL
    5 mM 1.8167 mL 9.0836 mL 18.1673 mL
    查看完整储备液配制表

    * 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
    储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)。-80°C储存时，请在6个月内使用，-20°C储存时，请在1个月内使用。

    * 备注：如您选择水作为储备液，请稀释至工作液后，再用 0.22 μm 的滤膜过滤除菌后使用。

    • 摩尔计算器

    • 稀释计算器

    Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

    质量
    =
    浓度
    ×
    体积
    ×
    分子量 *

    Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

    This equation is commonly abbreviated as: C1V1 = C2V2

    浓度 (start)

    C1

    ×
    体积 (start)

    V1

    =
    浓度 (final)

    C2

    ×
    体积 (final)

    V2

    动物实验：

    以下溶解方案，请直接配制工作液。建议现用现配，在短期内尽快用完。 以下溶剂前显示的百分比是指该溶剂在您配制终溶液中的体积占比； 如在配制过程中出现沉淀、析出现象，可以通过加热和/或超声的方式助溶。

    • 方案 一

      请依序添加每种溶剂： PBS

      Solubility: ≥ 100 mg/mL (908.36 mM); 澄清溶液

    动物溶解方案计算器
    请输入动物实验的基本信息：

    给药剂量

    mg/kg

    动物的平均体重

    g

    每只动物的给药体积

    μL

    动物数量

    只
    由于实验过程有损耗，建议您多配一只动物的量
    计算结果
    工作液所需浓度 : mg/mL
    该产品水溶性佳，请具体参考实测 水 / PBS / Saline 中的溶解度数据。
    您所需的储备液浓度超过该产品的实测溶解度，如有需要，请与 MCE 中国技术支持联系。
    纯度 & 产品资料

    纯度: ≥98.0%

    COA (282 KB) HNMR (229 KB)

    产品使用指南 (1538 KB)
    参考文献
    Cell Assay
    [1]

    Cells are seeded at a density of 2,000 cells/well in 96-well plates with 200 µL culture medium containing Sodium Butyrate at different concentrations. Then, the cells are consecutively cultured for 72 h. Every 24 h, 20 µL 5 mg/mL MTT solution is added into the corresponding well, and the cells are cultured for another 4 h. Then, the solution is replaced with 150 µL dimethylsulfoxide, followed by gentle agitation of the plates for 15 min at room temperature. Finally, the absorbance at 492 nm is measured to represent the cell viability.

    MCE has not independently confirmed the accuracy of these methods. They are for reference only.
    Animal Administration
    [2]

    Seven-day-old rat pups are subjected to unilateral carotid artery ligation followed by 60 min of hypoxia (7.6% O2). Sodium Butyrate (300 mg/kg) is administered in a 5-day regime with the first injection given immediately after hypoxic exposure. The damage of the ipsilateral hemisphere is evaluated by hematoxylin-eosin staining 6 days after the insult. Samples are collected at 24 and 48 h and 6 days.

    MCE has not independently confirmed the accuracy of these methods. They are for reference only.
    参考文献

    Sodium butyrate 相关分类

    完整储备液配制表

    * 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
    储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)。-80°C储存时，请在6个月内使用，-20°C储存时，请在1个月内使用。

    可选溶剂 浓度 溶剂体积 质量 1 mg 5 mg 10 mg 25 mg
    H2O 1 mM 9.0836 mL 45.4182 mL 90.8364 mL 227.0911 mL
    5 mM 1.8167 mL 9.0836 mL 18.1673 mL 45.4182 mL
    10 mM 0.9084 mL 4.5418 mL 9.0836 mL 22.7091 mL
    15 mM 0.6056 mL 3.0279 mL 6.0558 mL 15.1394 mL
    20 mM 0.4542 mL 2.2709 mL 4.5418 mL 11.3546 mL
    25 mM 0.3633 mL 1.8167 mL 3.6335 mL 9.0836 mL
    30 mM 0.3028 mL 1.5139 mL 3.0279 mL 7.5697 mL
    40 mM 0.2271 mL 1.1355 mL 2.2709 mL 5.6773 mL
    50 mM 0.1817 mL 0.9084 mL 1.8167 mL 4.5418 mL
    60 mM 0.1514 mL 0.7570 mL 1.5139 mL 3.7849 mL
    80 mM 0.1135 mL 0.5677 mL 1.1355 mL 2.8386 mL
    100 mM 0.0908 mL 0.4542 mL 0.9084 mL 2.2709 mL

    * 备注：如您选择水作为储备液，请稀释至工作液后，再用 0.22 μm 的滤膜过滤除菌后使用。

    Help & FAQs
    • Do most proteins show cross-species activity?

      Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

    Keywords:

    Sodium butyrate156-54-7Butanoic acidButyric acid丁酸钠HDACAutophagyApoptosisEndogenous MetaboliteHistone deacetylasesanti-tumor activityneuroprotectionnasopharyngeal carcinoma5-8F6-10BapoptosisInhibitorinhibitorinhibit

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