Spesolimab  (Synonyms: 佩索利单抗; BI 655130)

Spesolimab (BI 655130) is a mouse-derived humanized IgG1k antibody against IL-36R. IL-36 plays an important role in the immune system and Spesolimab is being investigated in palmoplantar pustulosis (PPP). Spesolimab was associated with a reduction in biomarkers associated with the innate, Th1/Th17 and neutrophil pathways^[1][2][3][4].

Human IgG1 kappa

Human IgG1 kappa, Isotype Control

Chimeric; Humanized

IL-36R^[1][2]

Spesolimab 的 K_a (M^-1s^-1) 为 1.36×10⁶，K_d (s^-1) 为 3.28×10^-5, K_D (pM) 为 24，在 NCI/ADR-RES 卵巢上皮细胞系中 IC₉₀ 为 0.9 nM，在人原代真皮成纤维细胞中的 IC₉₀ 为 1.9 nM^[4]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

2097104-58-8

液体

Colorless to light yellow

佩索利单抗

Shipping with dry ice.

Please store the product under the recommended conditions in the Certificate of Analysis.

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  Human IgG1 kappa

• [1]. Mrowietz U, et al. Spesolimab, an Anti-Interleukin-36 Receptor Antibody, in Patients with Palmoplantar Pustulosis: Results of a Phase IIa, Multicenter, Double-Blind, Randomized, Placebo-Controlled Pilot Study. Dermatol Ther (Heidelb). 2021 Apr;11(2):571-585.  [Content Brief]

  [2]. Geller S, et al. CCR4 expression in CD8+ cutaneous T-cell lymphomas and lymphoproliferative disorders and its implications for diagnosis and treatment[C]//Journal of Investigative Dermatology. STE 800, 230 PARK AVE, NEW YORK, NY 10169 USA: ELSEVIER SCIENCE INC, 2019, 139(9): B25-B25.

  [3]. Jennifer Ahlberg, et al. Retrospective analysis of model-based predictivity of human pharmacokinetics for anti-IL-36R monoclonal antibody MAB92 using a rat anti-mouse IL-36R monoclonal antibody and RNA expression data (FANTOM5). MAbs. 2019 Jul;11(5):956-964.  [Content Brief]

  [4]. Rajkumar Ganesan, et al. Generation and functional characterization of anti-human and anti-mouse IL-36R antagonist monoclonal antibodies.MAbs. 2017 Oct;9(7):1143-1154.  [Content Brief]