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  5. Splenopentin diacetate

Splenopentin diacetate  (Synonyms: 醋酸脾脏五肽)

目录号: HY-P0085
产品使用指南

摩尔计算器

Splenopentin diacetate 是一种合成的免疫调节性五肽，对应于脾脏激素脾脏蛋白的残基 32-36。Splenopentin diacetate 可影响早期的 T 细胞和 B 细胞分化，从而增加 γ 射线照射后小鼠体内抗体形成细胞的数量。

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Custom Peptide Synthesis

Splenopentin diacetate Chemical Structure

Splenopentin diacetate Chemical Structure

CAS No. : 105184-37-0

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规格 价格 是否有货 数量
1 mg ￥241
1 - 2 周
5 mg   询价  
10 mg   询价  

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Customer Review

Splenopentin diacetate 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Splenopentin diacetate is a synthetic immunomodulating pentapeptide corresponding to the residues 32-36 of the splenic hormone splenin. Splenopentin diacetate influences both early T and B cell differentiation, to increase the number of antibody-forming cells in mice after gamma irradiation[1][2].

体外研究
(In Vitro)

Splenopentin (1-100 μM) augments human NK cells and has no cytotoxicity[2].
Splenopentin (0.1 ng/mL-10 μg/mL; 3 h) induces phenotypic differentiation of both T- and B-cell precursor cells[3].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Splenopentin diacetate 相关抗体:
体内研究
(In Vivo)

Splenopentin (1 mg/kg; i.p. three times a week for 7-90 d) accelerates Langerhans cell recruitment and leads to pretreatment levels of Langerhans cell (LC) density in the skin of mice[4].
Splenopentin (0.01-100 μg per mouse; i.p.) has no demonstrable effect on neuromuscular transmission of mice[3].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Female Balb/c/Bln mice were injected Cyclophosphamide or Dexamethasone for 5 consecutive days[4]
Dosage: 1 mg/kg
Administration: I.p. three times a week for 7-90 days
Result: Reached the normal number of epidermal LCs at 28 days after the beginning of Cyclophosphamide treatment.
Accelerated restoration process and reached the normal LC density in the skin after 70 days in Dexamethasone treatment grops.
分子量

813.90

Formula

C35H59N9O13
CAS 号
中文名称

醋酸脾脏五肽
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
Solvent & Solubility
细胞实验： 

H2O

Peptide Solubility and Storage Guidelines:

1.  Calculate the length of the peptide.

2.  Calculate the overall charge of the entire peptide according to the following table:

  Contents Assign value
Acidic amino acid Asp (D), Glu (E), and the C-terminal -COOH. -1
Basic amino acid Arg (R), Lys (K), His (H), and the N-terminal -NH2 +1
Neutral amino acid Gly (G), Ala (A), Leu (L), Ile (I), Val (V), Cys (C), Met (M), Thr (T), Ser (S), Phe (F), Tyr (Y), Trp (W), Pro (P), Asn (N), Gln (Q) 0

3.  Recommended solution:

Overall charge of peptide Details
Negative (<0) 1.  Try to dissolve the peptide in water first.
2.  If water fails, add NH4OH (<50 μL).
3.  If the peptide still does not dissolve, add DMSO (50-100 μL) to solubilize the peptide.
Positive (>0) 1.  Try to dissolve the peptide in water first.
2.  If water fails, try dissolving the peptide in a 10%-30% acetic acid solution.
3.  If the peptide still does not dissolve, try dissolving the peptide in a small amount of DMSO.
Zero (=0) 1.  Try to dissolve the peptide in organic solvent (acetonitrile, methanol, etc.) first.
2.  For very hydrophobic peptides, try dissolving the peptide in a small amount of DMSO, and then dilute the solution with water to the desired concentration.
纯度 & 产品资料
参考文献

Splenopentin diacetate 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Splenopentin diacetate105184-37-0醋酸脾脏五肽OtherssyntheticimmunomodulatingpentapeptidesplenichormonespleninTBdifferentiationantibodyInhibitorinhibitorinhibit

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