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  4. Squalene synthase-IN-1

Squalene synthase-IN-1 (compound 1) 是一种有效的降血脂剂，通过抑制 Squalene Synthase 发挥作用。Squalene synthase-IN-1 具有出色的抗氧化和抗炎活性。Squalene synthase-IN-1 不仅能显着降低葡萄糖，还能显着降低氧化应激水平，同时不会引起任何毒性。

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Squalene synthase-IN-1 Chemical Structure

Squalene synthase-IN-1 Chemical Structure

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Squalene synthase-IN-1 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Squalene synthase-IN-1 (compound 1) is a potent antihyperlipidemic agent acting through Squalene Synthase inhibition. Squalene synthase-IN-1 exhibits an outstanding antioxidant and anti-inflammatory activity. Squalene synthase-IN-1 displays a significant reduction not only of glucose but also of oxidative stress levels, while it did not cause any toxicity[1].

体内研究
(In Vivo)

Squalene synthase-IN-1 (compound 1) (56 μmols/kg, 腹腔注射，每日2次) 具有抗高胆固醇/抗高血脂作用，可降低 TC 和 LDL 水平，并提高 HDL 水平[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Male ApoE−/− mice (10-12 weeks old, 24 to 28 g)[1]
Dosage: 56 μmols/kg (22.14 mg/kg)
Administration: i.p.,twice daily
Result: Displayed a powerful antihypercholesterolemic/antihyperlipidemic effect decreasing TC and LDL levels by 53% and 76%, respectively, and increasing HDL levels more than 100%.
分子量

395.31

Formula

C17H19BrN2O2S
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Squalene synthase-IN-1 相关分类

  • 摩尔计算器

  • 稀释计算器

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Squalene synthase-IN-1OthersInhibitorinhibitorinhibit

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