2. Anti-infection Epigenetics Cell Cycle/DNA Damage
  3. HIV HDAC DNA/RNA Synthesis
  4. ST7612AA1

ST7612AA1 是一种组蛋白去乙酰化酶 (HDAC) 抑制剂，通过去除组蛋白上的乙酰基来控制着染色质的凝聚和 DNA 的转录。ST7612AA1 也是一种有效的 HIV 再激活诱导剂，其再激活活性在不激活或增殖 CD4+T 细胞的情况下发挥，可用于 HIV 再激活策略和消灭病毒库的研究。

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ST7612AA1 Chemical Structure

ST7612AA1 Chemical Structure

CAS No. : 1428535-92-5

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规格 价格 是否有货 数量
1 mg ￥2240
1 - 2 周
5 mg ￥5600
1 - 2 周
10 mg 现货 1 - 2 周
50 mg   询价  
100 mg   询价  

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ST7612AA1 相关抗体

Top Publications Citing Use of Products

查看 HIV 亚型特异性产品:

查看所有亚型
HIV HIV-1 HIV-2

查看 HDAC 亚型特异性产品:

查看所有亚型
HDAC HDAC1 HDAC2 HDAC3 HDAC4 HDAC5 HDAC6 HDAC7 HDAC8 HDAC9 HDAC10 HDAC11 HD1 HD2

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

ST7612AA1 is a histone deacetylase (HDAC) inhibitor that controls chromatin condensation and DNA transcription by removing acetyl groups from histones. ST7612AA1 is also a potent HIV reactivation inducer, and its reactivation activity is exerted without activating or proliferating CD4+T cells, and can be used in the study of HIV reactivation strategies and elimination of viral reservoirs[1].

细胞效力
(Cellular Effect)
Cell Line Type Value Description References
HCT-116 IC50
0.075 μM
Compound: 117, ST7612
Cytotoxicity against human HCT116 cells after 24 hrs by SRB assay
Cytotoxicity against human HCT116 cells after 24 hrs by SRB assay
[PMID: 25233084]
NCI-H460 IC50
0.005 μM
Compound: 117, ST7612
Inhibition of HDAC-mediated histone H4 deacetylation in human NCI-H460 cells after 3 hrs by Western blot analysis
Inhibition of HDAC-mediated histone H4 deacetylation in human NCI-H460 cells after 3 hrs by Western blot analysis
[PMID: 25233084]
NCI-H460 IC50
0.07 μM
Compound: 117, ST7612
Cytotoxicity against human NCI-H460 cells after 24 hrs by SRB assay
Cytotoxicity against human NCI-H460 cells after 24 hrs by SRB assay
[PMID: 25233084]
NCI-H460 IC50
0.2 μM
Compound: 117, ST7612
Inhibition of HDAC-mediated tubulin deacetylation in human NCI-H460 cells after 3 hrs by Western blot analysis
Inhibition of HDAC-mediated tubulin deacetylation in human NCI-H460 cells after 3 hrs by Western blot analysis
[PMID: 25233084]
分子量

405.51

Formula

C20H27N3O4S
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

ST7612AA1 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

ST7612AA11428535-92-5HIVHDACDNA/RNA SynthesisHuman immunodeficiency virusHistone deacetylasesReactivation inducerTranscriptional activityCD4+T cellsInhibitorinhibitorinhibit

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ST7612AA1
目录号：
HY-12926
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