2. PI3K/Akt/mTOR Stem Cell/Wnt JAK/STAT Signaling Apoptosis
  3. Akt STAT Apoptosis
  4. STAT3/AKT-IN-1

STAT3/AKT-IN-1 是信号转导子和转录激活子 3 (STAT3) 和蛋白激酶 B (AKT) 信号通路的双重抑制剂，具有抗肿瘤活性并诱导 SGC-7901 细胞凋亡 (apoptosis)。

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STAT3/AKT-IN-1 Chemical Structure

STAT3/AKT-IN-1 Chemical Structure

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STAT3/AKT-IN-1 相关抗体

Top Publications Citing Use of Products

查看 Akt 亚型特异性产品:

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Akt Akt1 Akt2 Akt3

查看 STAT 亚型特异性产品:

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STAT3 STAT5 STAT6 STAT1

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

STAT3/AKT-IN-1 is a dual inhibitor for the signal transducer and activator of transcription 3 (STAT3) and protein kinase B (AKT) signalling pathway, exhibits antitumor activity against gastric cancer and induces cell apoptosis in SGC-7901 cells[1].

IC50 & Target

Stat-3

 

体外研究
(In Vitro)

STAT3/AKT-IN-1 抑制胃癌细胞 SGC-7901 和 BGC-823 的细胞活力，IC50 分别为 1.39 μM 和 2.92 μM[1]。
STAT3/AKT-IN-1 (2.5-10 μM) 剂量依赖地在 G2/M 期阻滞细胞周期，抑制 SGC-7901 细胞增殖和迁移，诱导细胞凋亡[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

STAT3/AKT-IN-1 相关抗体:

Cell Migration Assay [1]

Cell Line: SGC-7901
Concentration: 2.5-10 μM
Incubation Time: 48 h
Result: Inhibited migration of SGC-7901 cells.

Cell Cycle Analysis[1]

Cell Line: SGC-7901
Concentration: 2.5-10 μM
Incubation Time: 48 h
Result: Arrested cell cycle at G2/M phase.

Western Blot Analysis[1]

Cell Line: SGC-7901
Concentration: 2.5-10 μM
Incubation Time: 18 h
Result: Inhibited phosphorylation of AKT (Ser473) and STAT3 (Tyr705).
体内研究
(In Vivo)

STAT3/AKT-IN-1 (15 mg/kg静脉注射，每天一次共 20 天) 在 SGC-7901 异种移植 BALB/c 小鼠中表现出抗癌活性，且没有明显毒性[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: SGC-7901 xenografted BALB/c mice[1]
Dosage: 15 mg/kg
Administration: i.p. once daily for 20 days
Result: Inhibited tumor growth without weight loss.
分子量

362.42

Formula

C23H22O4
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

STAT3/AKT-IN-1 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

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浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

STAT3/AKT-IN-1AktSTATApoptosisPKBProtein kinase Bgastric cancerSGC-7901BGC-823STAT3AKTInhibitorinhibitorinhibit

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