2. JAK/STAT Signaling Stem Cell/Wnt
  3. STAT
  4. STAT5-IN-3

STAT5-IN-3 (Compound 14a) 是 STAT5 抑制剂，具有抗癌活性。STAT5-IN-3 通过阻断 STAT5A/5B 的酪氨酸磷酸化 (Y694/699 位点)，并显著降低 STAT5B 蛋白的表达，从而抑制下游基因转录，阻断白血病细胞的增殖和生存。此外，STAT5-IN-3 在克服化疗耐药性方面也具有重要价值。

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STAT5-IN-3 Chemical Structure

STAT5-IN-3 Chemical Structure

1.  客户无需承担相应的运输费用。

2.  同一机构（单位）同一产品试用装仅限申领一次，同一机构（单位）一年内

     可免费申领三个不同产品的试用装。

3.  试用装只面向终端客户。

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Customer Review

STAT5-IN-3 相关抗体

Top Publications Citing Use of Products

查看 STAT 亚型特异性产品:

查看所有亚型
STAT3 STAT5 STAT6 STAT1

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

STAT5-IN-3 (Compound 14a) is a STAT5 inhibitor with anticancer activity. STAT5-IN-3 blocks the tyrosine phosphorylation of STAT5A/5B at the Y694/699 sites and significantly reduces the expression of STAT5B protein, thereby inhibiting downstream gene transcription and blocking the proliferation and survival of leukemia cells. Additionally, STAT5-IN-3 holds significant value in overcoming chemotherapy resistance[1].

体外研究
(In Vitro)

STAT5-IN-3 (Compound 14a) (100 nM-10 μM; 48 h) 能抑制髓系白血病细胞 (KU812、K562、KCL-22、MV-4-11 和 MOLM-13) 的活性，EC50 值分别 0.6 μM、0.8 μM、0.5 μM、0.3 μM 和 0.3 μM，而对正常细胞 (HS27A 和 MSC) 的毒性较低，其 EC50 值均 > 10 μM[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

STAT5-IN-3 相关抗体:
分子量

413.51

Formula

C25H27N5O
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

STAT5-IN-3 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

STAT5-IN-3STATleukemiaKU812K562KCL-22MV-4-11MOLM-13HS27AMSCantileukemic activityInhibitorinhibitorinhibit

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产品名称：
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目录号：
HY-170837
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