2. Metabolic Enzyme/Protease
  3. Steroid Sulfatase
  4. Steroid sulfatase/17β-HSD1-IN-5

Steroid sulfatase/17β-HSD1-IN-5 

目录号: HY-155010
产品使用指南

摩尔计算器

Steroid sulfatase/17β-HSD1-IN-5 是类固醇硫酸酯酶 (STS) 的不可逆抑制剂，也是 17β - 羟甾类固醇脱氢酶 1 型 (17β-HSD1) 的可逆和选择性抑制剂，对 17β-HSD1 和 17β-HDS1 的 IC50s 分别为 43 nM 和 6.2 μM。Steroid sulfatase/17β-HSD1-IN-5 可用于代谢性疾病（尤其是子宫内膜异位症）的研究。

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Steroid sulfatase/17β-HSD1-IN-5 Chemical Structure

Steroid sulfatase/17β-HSD1-IN-5 Chemical Structure

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Steroid sulfatase/17β-HSD1-IN-5 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Steroid sulfatase/17β-HSD1-IN-5 is a irreversible inhibitor of steroid sulfatase (STS) .Steroid sulfatase/17β-HSD1-IN-5 is a reversible and selective inhibitor of 7β-hydroxysteroid dehydrogenase type1 (17β-HSD1), with IC50s of 43 nM and 6.2μM for 17β-HSD1 and 17β-HSD2, respectively. Steroid sulfatase/17β-HSD1-IN-5 can be used for metabolic disease (especially for endometriosis) research[1].

IC50 & Target

IC50: 43 nM (17β-HSD 1)[1]
IC50: 6.3 μM (17β-HSD 2)[1]
IC50: 0.4 μM (Steroid sulfatase)[1]
体外研究
(In Vitro)

Steroid sulfatase/17β-HSD1-IN-5 (Compound 5) (0-40 μM；48-72 小时) 在浓度高达 31 μM (HEK293) 和 23 μM (HepG2)时，对细胞活力没有影响[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Steroid sulfatase/17β-HSD1-IN-5 相关抗体:

Cell Viability Assay[1]

Cell Line: HEK293 and HepG2 cells
Concentration: 0-30 μΜ
Incubation Time: 48-72 hours
Result: Had no effect on cell viability up to 31 μM (HEK293) and 23 μM (HepG2), respectively.
体内研究
(In Vivo)

Steroid sulfatase/17β-HSD1-IN-5 (Compound 5) (皮下注射，50 mg/kg，单次给药) 显示 T1/2 为 3.82 小时，和 Cmax obs 为 2824 nM[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Female C57BL/6 mice (Pharmacokinetic assay)[1]
Dosage: 50 mg/kg
Administration: Subcutaneous injection (s.c.), single dose
Result: Pharmacokinetic parameters for Steroid sulfatase/17β-HSD1-IN-5 (Compound 5) in female C57BL/6 mice [1]
Route Dose (mg/kg) Cmax obs (nM) C24 (nM) T1/2z (h) AUC0-24 (ng•h/mL)
s.c. 50 2824 797 3.82 11600
分子量

430.47

Formula

C21H22N2O6S
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Steroid sulfatase/17β-HSD1-IN-5 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Steroid sulfatase/17β-HSD1-IN-5Steroid SulfataseSteroid sulfataseendometriosis17β-HSD117β-HSD2HEK293HepG2Inhibitorinhibitorinhibit

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