2. Immunology/Inflammation
  3. Mucin
  4. Surzebiclimab

Surzebiclimab  (Synonyms: BGB-A425)

目录号: HY-P99962 纯度: 95.00%
COA

摩尔计算器

Surzebiclimab (BGB-A425) 是一种人源化 IgG1 变体单克隆抗体，抗 T 细胞免疫球蛋白和含粘蛋白结构域 3 (TIM-3)。Surzebiclimab 与人 Tim-3 细胞外结构域结合具有较高的亲和力 (KD=0.36 nM) 和特异性。Surzebiclimab 可用于癌症研究。

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     可免费申领三个不同产品的试用装。

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规格 价格 是否有货 数量
1 mg ￥3500
In-stock
5 mg ￥9100
In-stock
10 mg   询价  
50 mg   询价  

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Customer Review

Surzebiclimab 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Surzebiclimab (BGB-A425) is a humanized IgG1-variant monoclonal antibody against T-cell immunoglobulin and mucin-domain containing-3 (TIM-3). Surzebiclimab binds to the extracellular domain of human Tim-3 with high affinity (KD=0.36 nM) and specificity. Surzebiclimab can be used in research of cancer[1].

同型

Human IgG1 kappa
推荐同型对照抗体
种属

Humanized
体外研究
(In Vitro)

Surzebiclimab (BGB-A425; 0.1-100 μg/mL) 有效阻断 Tim-3 和 PtdSer 之间的相互作用。Surzebiclimab 增强原代 T 细胞的 IFN-γ 产生和 NK 介导的对肿瘤细胞的细胞毒性[1]。
Surzebiclimab 单独或与抗 PD-1 抗体 BGB-A317 联合使用可增强 T 细胞对同种异体抗原的反应。Surzebiclimab 还可以诱导细胞表面 Tim-3 受体的内化[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Surzebiclimab 相关抗体:
体内研究
(In Vivo)

surzebiclimb (BGB-A425) 联合 BGB-A317 在小鼠异种移植瘤模型中抑制肿瘤生长[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
Clinical Trial
性状

液体

颜色

Colorless to light yellow

运输条件

Shipping with dry ice.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
Format
  • Human IgG1 kappa
纯度 & 产品资料
参考文献

Surzebiclimab 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

SurzebiclimabBGB-A425Mucinhumanized monoclonal antibodyIFN-γprimary T cellsNK-mediated cytotoxicitycancerInhibitorinhibitorinhibit

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