2. Metabolic Enzyme/Protease
  3. Drug Metabolite
  4. T-705RMP

T-705RMP 是 T-705 的磷酸化代谢产物，对宿主细胞 IMP 脱氢酶 (IMPDH) 活性的抑制作用很弱，IC50 为 601 μM。

在相同的摩尔浓度下，化合物盐形式与游离形式有相同的生物活性，但盐形式 T-705RMP ammonium 通常具有更好的水溶性和稳定性。

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T-705RMP Chemical Structure

T-705RMP Chemical Structure

CAS No. : 356783-08-9

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T-705RMP 的其他形式现货产品:

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T-705RMP 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

T-705RMP, a phosphorylated metabolite of T-705, exhibits a very weak inhibitory effect on the IMP dehydrogenase (IMPDH) activities of the host cells, with an IC50 of 601 μM[1].

体外研究
(In Vitro)

T-705 can be converted to T-705RMP and T-705RTP by cellular kinases; Host cell enzymes can differentiate T-705, T-705RMP, and T-705RTP from the natural nucleotides. The level of inhibition of IMPDH by T-705RMP is about 150-fold weaker than that by Ribavirin monophosphate, and it became apparent that the antiviral effect of T-705 is not a result of the inhibition of the cellular enzyme[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

T-705RMP 相关抗体:
分子量

369.20

Formula

C10H13FN3O9P
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

T-705RMP 相关分类

  • 摩尔计算器

  • 稀释计算器

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  • Do most proteins show cross-species activity?

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Keywords:

T-705RMP356783-08-9Drug MetabolitephosphorylatedmetaboliteIMPDHhostcellsInhibitorinhibitorinhibit

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