2. Apoptosis
  3. TNF Receptor
  4. Tabalumab

Tabalumab  (Synonyms: 他贝芦单抗; LY2127399)

目录号: HY-P99220 纯度: 98.11%
COA

摩尔计算器

Tabalumab (LY2127399) 是一种人源的抗 BAFF (B细胞激活因子) 单克隆抗体 (IgG4 型)，对膜结合和可溶性 BAFF 具有中和活性。Tabalumab 可用于自身免疫性疾病，如类风湿性关节炎、肾衰竭和系统性红斑狼疮的研究。

MCE 的所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务

我们将采用定制合成服务的方式为您快速提供所需产品和技术服务

CAS No. : 1143503-67-6

1.  客户无需承担相应的运输费用。

2.  同一机构（单位）同一产品试用装仅限申领一次，同一机构（单位）一年内

     可免费申领三个不同产品的试用装。

3.  试用装只面向终端客户。

规格 价格 是否有货 数量
1 mg ￥1200
In-stock
5 mg ￥3600
In-stock
10 mg ￥6100
In-stock
50 mg   询价  
100 mg   询价  

* Please select Quantity before adding items.

Customer Review

Tabalumab 相关抗体

Top Publications Citing Use of Products

查看 TNF Receptor 亚型特异性产品:

查看所有亚型
TNFRSF1A/CD120a TNFRSF5/CD40 TNFRSF6/Fas/CD95 TNFRSF8/CD30 TNFRSF9/4-1BB/CD137 TNFRSF16/NGF Receptor/CD271 TNFRSF18/GITR/CD357

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Tabalumab (LY2127399) is a human anti-BAFF (B-cell activating factor) monoclonal antibody (IgG4 type) with neutralising activity against membrane bound and soluble BAFF. Tabalumab can be used in studies of autoimmune diseases such as rheumatoid arthritis, renal failure and systemic lupus erythematosus[1].

同型

Human IgG4 kappa
推荐同型对照抗体
种属

Human
IC50 & Target

BAFF[1].
体外研究
(In Vitro)

Tabalumab (1-100 ng/mL; 44 h) neutralizes soluble and membrane-bound BaFF both in T1165.17 cells and (1 μg/mL; 3 days) CD19+ B-cells[1].
Tabalumab (50 μg/mL; 15 min) inhibits BaFF binding to BR3, TacI, and BcMa in HEK293 cells[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Tabalumab 相关抗体:

Cell Viability Assay[1]

Cell Line: T1165.17 cells
Concentration: 1-100 ng/mL
Incubation Time: 44 h
Result: Neutralizeed tabalumab neutralization of soluble human, cynomolgus monkey, or rabbit BAFF with IC50 values of 104, 143, and 176 pM in T1165.17 cells, respectively.

Cell Viability Assay[1]

Cell Line: CD19+ B-cells
Concentration: 1 µg/mL
Incubation Time: 3 days
Result: Demonstrated the ability to neutralize the membrane-bound form of BAFF compared with the soluble form of BAFF.

Cell Viability Assay[1]

Cell Line: HEK293 cells (transfected with either BR3, TACI, or BCMA)
Concentration: 50 µg/mL
Incubation Time: 15 min (pre-treat)
Result: Prevented the binding of BAFF to BR3, TACI, or BCMA on the cell surface.
体内研究
(In Vivo)

Tabalumab (500 μg/rat; s.c.; single) leads to decreased B-cells and a reduction in non-canonical nF-κB signaling[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Human BAFF Tg mice[1].
Dosage: 500 µg/rat
Administration: Subcutaneous injection, single.
Result: Significantly decreased the splenic B-cell count between day 4 and 8.
Decreased levels of p52, which returned to near the BAFF Tg level at Day 23.
Clinical Trial
CAS 号
性状

液体

颜色

Colorless to light yellow

中文名称

他贝芦单抗
运输条件

Shipping with dry ice.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
Format
  • Human IgG4 kappa
纯度 & 产品资料
参考文献

Tabalumab 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Tabalumab1143503-67-6LY2127399他贝芦单抗LY 2127399LY-2127399TNF ReceptorTumor Necrosis Factor ReceptorTNFRrheumatoid arthritissystemic lupus erythematosusIgG4autoimmune diseasesT1165.17CD19+ B-cellsHEK293Inhibitorinhibitorinhibit

您最近查看的产品:

Your information is safe with us. * Required Fields.

   产品名称：

  

* 需求量：

* 客户姓名：

 

* Email：

* 电话：

 

* 公司或机构名称：

   留言给我们：

Bulk Inquiry

Inquiry Information

产品名称：
Tabalumab
目录号：
HY-P99220
需求量：

Request for HNMR Report

Please fill out this form to request the QC report. We will send it to your Email address shortly.

Your information is safe with us. * Required Fields.

   产品名称：

  

* Lot #：

* 客户姓名：

 

* Email：

   电话：

 

* 部门：

* 公司或机构名称：

 

   留言给我们：

Request for HNMR Report

We have received your request and will respond to you as soon as possible.

嗨！很高兴为您提供帮助！

尊敬的 MCE 客户您好，
请您选择所在区域，我们将转接对应客服为您服务！

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z

热 A B C F G H J L N Q S T X Y Z