2. Apoptosis
  3. Photosensitizer
  4. Talaporfin

Talaporfin  (Synonyms: ME2906 free acid; Mono-L-aspartyl chlorin e6 free acid; NPe6 free acid)

目录号: HY-16477A
产品使用指南 技术支持

Talaporfin 可用于组建术中光动力疗法 (PDT)，来抑制原发性恶性实质性脑肿瘤。

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Talaporfin Chemical Structure

Talaporfin Chemical Structure

CAS No. : 110230-98-3

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规格 是否有货
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Talaporfin 的其他形式现货产品:

Customer Review

Other Forms of Talaporfin:

Talaporfin 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Talaporfin sodium, can be used in intraoperative photodynamic therapy (PDT) with a 664-nm semiconductor laser, was evaluated for efficacy and safety in treating primary malignant parenchymal brain tumors[1].

细胞效力
(Cellular Effect)
Cell Line Type Value Description References
A549 IC50
181 μM
Compound: Talaporfin
Dark toxicity in human A549 cells assessed as reduction in cell viability incubated under dark for 48 hrs measured after 48 hrs by CCK8 assay
Dark toxicity in human A549 cells assessed as reduction in cell viability incubated under dark for 48 hrs measured after 48 hrs by CCK8 assay
[PMID: 33744687]
A549 IC50
256 μM
Compound: Talaporfin
Cytotoxicity against human A549 cells assessed as reduction in cell viability incubated for 48 hrs by CCK-8 assay
Cytotoxicity against human A549 cells assessed as reduction in cell viability incubated for 48 hrs by CCK-8 assay
[PMID: 32846322]
A549 IC50
6.21 μM
Compound: Talaporfin
Phototoxicity in human A549 cells assessed as reduction in cell viability irradiated 10 j/cm2 for 24 hrs followed by incubated for 24 hrs by CCK8 assay
Phototoxicity in human A549 cells assessed as reduction in cell viability irradiated 10 j/cm2 for 24 hrs followed by incubated for 24 hrs by CCK8 assay
[PMID: 33744687]
A549 IC50
8.73 μM
Compound: Talaporfin
Phototoxicity against human A549 cells assessed as reduction in cell viability incubated for 24 hrs followed by irradiated with 10 J/cm2 660 nanometer visible light and measured after 24 hrs hrs by CCK-8 assay
Phototoxicity against human A549 cells assessed as reduction in cell viability incubated for 24 hrs followed by irradiated with 10 J/cm2 660 nanometer visible light and measured after 24 hrs hrs by CCK-8 assay
[PMID: 32846322]
B16-F10 IC50
14 μM
Compound: Talaporfin
Phototoxicity against mouse B16-F10 cells assessed as reduction in cell viability incubated for 24 hrs followed by irradiated with 10 J/cm2 660 nanometer visible light and measured after 24 hrs hrs by CCK-8 assay
Phototoxicity against mouse B16-F10 cells assessed as reduction in cell viability incubated for 24 hrs followed by irradiated with 10 J/cm2 660 nanometer visible light and measured after 24 hrs hrs by CCK-8 assay
[PMID: 32846322]
B16-F10 IC50
303 μM
Compound: Talaporfin
Cytotoxicity against mouse B16-F10 cells assessed as reduction in cell viability incubated for 48 hrs by CCK-8 assay
Cytotoxicity against mouse B16-F10 cells assessed as reduction in cell viability incubated for 48 hrs by CCK-8 assay
[PMID: 32846322]
HCT-116 IC50
2.95 μM
Compound: Talaporfin
Phototoxicity in human HCT-116 cells assessed as reduction in cell viability irradiated 10 j/cm2 for 24 hrs followed by incubated for 24 hrs by CCK8 assay
Phototoxicity in human HCT-116 cells assessed as reduction in cell viability irradiated 10 j/cm2 for 24 hrs followed by incubated for 24 hrs by CCK8 assay
[PMID: 33744687]
HCT-116 IC50
50.72 μM
Compound: Talaporfin
Dark toxicity in human HCT-116 cells assessed as reduction in cell viability incubated under dark for 48 hrs measured after 48 hrs by CCK8 assay
Dark toxicity in human HCT-116 cells assessed as reduction in cell viability incubated under dark for 48 hrs measured after 48 hrs by CCK8 assay
[PMID: 33744687]
HeLa IC50
> 300 μM
Compound: Talaporfin
Cytotoxicity against human HeLa cells assessed as reduction in cell viability incubated for 48 hrs by CCK-8 assay
Cytotoxicity against human HeLa cells assessed as reduction in cell viability incubated for 48 hrs by CCK-8 assay
[PMID: 32846322]
HeLa IC50
5.92 μM
Compound: Talaporfin
Phototoxicity against human HeLa cells assessed as reduction in cell viability incubated for 24 hrs followed by irradiated with 10 J/cm2 660 nanometer visible light and measured after 24 hrs hrs by CCK-8 assay
Phototoxicity against human HeLa cells assessed as reduction in cell viability incubated for 24 hrs followed by irradiated with 10 J/cm2 660 nanometer visible light and measured after 24 hrs hrs by CCK-8 assay
[PMID: 32846322]
分子量

711.76

Formula

C38H41N5O9
CAS 号
中文名称

他拉泊芬
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Talaporfin 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Talaporfin110230-98-3ME2906Mono-L-aspartyl chlorin e6NPe6他拉泊芬ME 2906ME-2906NPe 6NPe-6PhotosensitizerInhibitorinhibitorinhibit

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