2. Metabolic Enzyme/Protease Cell Cycle/DNA Damage
  3. Dihydrofolate reductase (DHFR) Antifolate
  4. Talotrexin monoammonium

Talotrexin monoammonium  (Synonyms: PT523 monoammonium)

目录号: HY-10824A
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摩尔计算器

Talotrexin monoammonium 是 Talotrexin (HY-10824) 的单铵盐形式。Talotrexin monoammonium 是一种 Aminopterin (HY-14518) 的类似物，是一种非聚谷氨酸化的经典抗叶酸剂 (antifolate)。Talotrexin monoammonium 是一种还原型叶酸载体 (RFC) 的特异性抑制剂，可选择性地抑制 RFC 转运。Talotrexin monoammonium 通过靶向 DHFR 抑制肿瘤生长显示出抗肿瘤活性。

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Talotrexin monoammonium Chemical Structure

Talotrexin monoammonium Chemical Structure

CAS No. : 648420-92-2

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规格 价格 是否有货 数量
1 mg ￥3640
1 - 2 周
5 mg   询价  
10 mg   询价  

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Other Forms of Talotrexin monoammonium:

Talotrexin monoammonium 相关抗体

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  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Talotrexin monoammonium is the monoammonium salt form of Talotrexin (HY-10824). Talotrexin monoammonium is an analog of Aminopterin (HY-14518), and is a nonpolyglutamatable classic antifolate. Talotrexin monoammonium is a reduced folate carrier (RFC) specific inhibitor and selectively inhibits RFC transport. Talotrexin monoammonium shows antitumor activity by targeting DHFR to inhibit tumor growth[1][2].

分子量

590.59

Formula

C27H30N10O6
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Talotrexin monoammonium 相关分类

  • 摩尔计算器

  • 稀释计算器

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Talotrexin monoammonium648420-92-2PT523 monoammoniumDihydrofolate reductase (DHFR)AntifolateR1-11Tet-on-RFCHeLa cellsDHFRreduced folate carrierantifolateNSCLCA549 tumorInhibitorinhibitorinhibit

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