2. Vitamin D Related/Nuclear Receptor
  3. Estrogen Receptor/ERR
  4. Taragarestrant

Taragarestrant  (Synonyms: D-0502)

目录号: HY-147402
产品使用指南

摩尔计算器

Taragarestrant (D-0502) 是一种有效的、具有口服活性的、选择性的雌激素受体 (estrogen receptor) 降解剂。Taragarestrant 在各种 ER+ 乳腺癌细胞系和移植模型中显示出强大的活性。

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Taragarestrant Chemical Structure

Taragarestrant Chemical Structure

CAS No. : 2118899-51-5

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Taragarestrant 的其他形式现货产品:

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Other Forms of Taragarestrant:

Taragarestrant 相关抗体

Top Publications Citing Use of Products

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Estrogen receptor ERα ERβ ERRα ERRβ ERRγ

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Taragarestrant (D-0502) is a potent, orally active and selective estrogen receptor degrader (SERD). Taragarestrant shows potent activity in various ER+ breast cancer cell lines and xenograft models[1][2].

细胞效力
(Cellular Effect)
Cell Line Type Value Description References
ES-2 IC50
46.4 nM
Compound: D4
Displacement of Fluormone ES2 from full length human ERalpha incubated for 60 min by fluorescent polarization assay
Displacement of Fluormone ES2 from full length human ERalpha incubated for 60 min by fluorescent polarization assay
[PMID: 34056898]
MCF7 IC50
2.07 nM
Compound: D4
Antiproliferative activity against human MCF7 cells assessed as inhibition of cell proliferation incubated for 5 days by Cell Titer Glo assay
Antiproliferative activity against human MCF7 cells assessed as inhibition of cell proliferation incubated for 5 days by Cell Titer Glo assay
[PMID: 34056898]
体内研究
(In Vivo)

Taragarestrant (D-0502) 具有优秀的药代动力学特性[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
Clinical Trial
分子量

475.38

Formula

C25H25Cl2FN2O2
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Taragarestrant 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Taragarestrant2118899-51-5D-0502D0502D 0502Estrogen Receptor/ERRbreast cancer cellanticancerorally activeSERDInhibitorinhibitorinhibit

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