2. Immunology/Inflammation
  3. Toll-like Receptor (TLR)
  4. TAT-CIRP

TAT-CIRP 是一种小肽，是指反式反式激活 (Tat) 冷诱导 RNA 结合蛋白。TAT-CIRP 是骨髓分化蛋白 2 (MD2) 的抑制剂。TAT-CIRP 对小鼠缺血性和出血性中风表现出强大的神经保护作用。

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Custom Peptide Synthesis

TAT-CIRP Chemical Structure

TAT-CIRP Chemical Structure

1.  客户无需承担相应的运输费用。

2.  同一机构（单位）同一产品试用装仅限申领一次，同一机构（单位）一年内

     可免费申领三个不同产品的试用装。

3.  试用装只面向终端客户。

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Customer Review

TAT-CIRP 相关抗体

Top Publications Citing Use of Products

查看 Toll-like Receptor (TLR) 亚型特异性产品:

查看所有亚型
TLR3 TLR8 TLR9 TLR2 TLR4 TLR7 TLR1 TLR6

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

TAT-CIRP is a a small peptide, refers to Trans-trans-activating (Tat)-cold-inducible RNA binding protein. TAT-CIRP is an inhibitor of myeloid differentiation protein 2 (MD2). TAT-CIRP exhibits robust neuroprotection against ischemic and hemorrhagic stroke in mice[1].

体外研究
(In Vitro)

TAT-CIRP (5 μM) 通过 TLR4 非依赖性途径，减轻神经细胞中 NMDA 刺激（50 μM；1 小时）诱导的细胞凋亡和坏死[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

TAT-CIRP 相关抗体:
体内研究
(In Vivo)

TAT-CIRP (5-20mg/kg) 减轻大脑中动脉 (MCA) 闭塞 (MCAO) 小鼠缺血性中风后的脑损伤。至于 Tat，人类免疫缺陷病毒 1 型的细胞膜转导结构域，可用作对照肽[1]。
TAT-CIRP (20 mg/kg；静脉注射；单剂量) 在小鼠中可通过血脑屏障，Cmax 值为 4762.6 μg/L，半衰期约为 90 分钟[1]。
TAT-CIRP (20 mg/kg、100 mg/kg；静脉注射；每天一次，持续 7 天) 对小鼠几乎没有毒性，具有安全性[1]。
TAT-CIRP 减少恒河猴的脑缺血损伤[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Middle cerebral artery (MCA) occlusion (MCAO) model in mouse[1]
Dosage: 5 mg/kg, 10 mg/kg, 20 mg/kg
Administration: IV; single dose or once daily for 7 days
Result: Resulted better neurological function at 28 days after brain hemorrhage than the mice that received saline.
Did not induce elevation of any liver transaminases or biomarkers of renal dysfunction.
分子量

2997.31

Formula

C123H206N56O33
性状

固体

颜色

White to off-white

Sequence

Tyr-Gly-Arg-Lys-Lys-Arg-Arg-Gln-Arg-Arg-Arg-Gly-Arg-Gly-Phe-Ser-Arg-Gly-Gly-Gly-Asp-Arg-Gly-Tyr-Gly-Gly
Sequence Shortening

YGRKKRRQRRRGRGFSRGGGDRGYGG
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Sealed storage, away from moisture and light, under nitrogen

Powder -80°C 2 years
-20°C 1 year

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light, under nitrogen)

纯度 & 产品资料
参考文献

TAT-CIRP 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

TAT-CIRPToll-like Receptor (TLR)Trans-trans-activatingcold-inducible RNA binding proteinmyeloid differentiation protein 2neuronal injuryneuroprotection against ischemichemorrhagic strokeblood-brain barrierInhibitorinhibitorinhibit

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目录号：
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