2. Apoptosis
  3. Apoptosis
  4. Tat-NTS peptide

Tat-NTS peptide 是细胞穿透肽，具有神经保护作用。Tat-NTS peptide 能特异性的抑制 ANXA1 的核易位，减少缺血区的神经元凋亡 (apoptosis)。并且 Tat-NTS peptide 能减少脑缺血性梗死体积，可以用于缺血性卒中的研究。

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Custom Peptide Synthesis

Tat-NTS peptide Chemical Structure

Tat-NTS peptide Chemical Structure

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Tat-NTS peptide 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Tat-NTS peptide is a cell-penetrating peptide with neuroprotective effects. Tat-NTS peptide can specifically inhibit the nuclear translocation of ANXA1 and reduce neuronal apoptosis in ischemic areas. Moreover, Tat-NTS peptide can reduce the volume of cerebral ischemic infarction and can be used in the research of ischemic stroke[1].

体外研究
(In Vitro)

Tat-NTS peptide (20 μM) 在神经元细胞中能阻断 ANXA1 核迁移而不影响其他蛋白的核易位[1]。
Tat-NTS peptide (20 μM) 能抑制 ANXA1 与 p53 的结合，减轻氧葡萄糖剥夺/再灌注 (OGD/R) 诱导的神经元凋亡，具有神经元细胞保护作用[1]。
Tat-NTS peptide (20 μM) 可显著提高 OGD/R 后的神经元细胞的活力[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Tat-NTS peptide 相关抗体:

Western Blot Analysis[1]

Cell Line: neuronal cells
Concentration: 20 μM
Incubation Time:
Result: Significantly decreased the level of ANXA1 protein in the nuclear fraction, and had no impact on the subcellular localization of p65 and β-catenin.
Significantly decreased Bid protein levels.
Significantly decreased OGD/R-triggered tBid expression and caspase-9, PARP, caspase-3 cleavage but had little effect on the activation of caspase-8.

RT-PCR[1]

Cell Line: neuronal cells
Concentration: 20 μM
Incubation Time:
Result: Significantly decreased Bid mRNA levels.
体内研究
(In Vivo)

Tat-NTS peptide (0.5-10 mg/kg; 侧脑室注射; 单剂量) 在大脑动脉闭塞 (MCAO) C57BL/6 小鼠中减少 ANXA1 与 importin β 的相互作用，并阻止 ANXA1 在体内的核易位。Tat-NTS peptide 减轻小鼠缺血损伤后神经元细胞凋亡，具有脑缺血的神经保护作用[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: MCAO C57BL/6 mice model[1]
Dosage: 0.5 mg/kg, 1 mg/kg, 2 mg/kg, 5 mg/kg, 10 mg/kg.
Administration: Unilateral Intracerebroventricular (i.c.v.) Injection: Single dose. After undergoing 1-hour middle cerebral artery occlusion (MCAO)
Result: Significantly inhibited the protein level of tBid, cleaved caspase-9, cleaved PARP, and caspase-3, and had little effect on the activation of caspase-8.
Reduced the infarct volume and improved neurological outcomes following focal ischemic injury.
分子量

2855.37

Formula

C125H212N54O24
Sequence

Tyr-Gly-Arg-Lys-Lys-Arg-Arg-Gln-Arg-Arg-Arg-Arg-Ser-Phe-Pro-His-Leu-Arg-Arg-Val-Phe-NH2
Sequence Shortening

YGRKKRRQRRRRSFPHLRRVF-NH2
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Tat-NTS peptide 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Tat-NTS peptideApoptosisC57BL/6 miceneuronal apoptosisoxygen glucose deprivation/reperfusion (OGD/R)middle cerebral artery occlusion (MCAO)neuroprotectantischemic strokeInhibitorinhibitorinhibit

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