2. 多肽产品
  3. 多肽及其衍生物
  4. 抑制剂与底物肽
  5. TAT-P4-(DATC5)2

TAT-P4-(DATC5)2 是一种蛋白激酶 C 相互作用蛋白 1 PDZ 结构域 (PICK1 PDZ domain) 的高亲和力多肽抑制剂，其 Ki 值为 1.7 nM。TAT-P4-(DATC5)2 在大鼠成瘾实验中起抑制作用。

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Custom Peptide Synthesis

TAT-P4-(DATC5)2 Chemical Structure

TAT-P4-(DATC5)2 Chemical Structure

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Other Forms of TAT-P4-(DATC5)2:

TAT-P4-(DATC5)2 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

TAT-P4-(DATC5)2 is a high-affinity peptide inhibitor of the PICK1 (protein interacting with C kinase-1) PDZ domain, with a Ki of 1.7 nM. TAT-P4-(DATC5)2 can inhibit addiction in rats[1].

IC50 & Target

Ki: 1.7 nM (PICK1 PDZ domain)[1]
体内研究
(In Vivo)

TAT-P4-(DATC5)2 (0.99 μg/kg，9.9 μg/kg；静脉内输注) 以剂量依赖性方式减弱大鼠体内成瘾剂寻觅的恢复，剂量不会产生操作性学习缺陷或抑制运动活动[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Male Sprague-Dawley rats (250-300 g) [1]
Dosage: 0.99 μg/kg, 9.9 μg/kg
Administration: Infused intravenously, 45 min prior to an acute injection of cocaine (10 mg/kg, i.p.)
Result: Attenuated the reinstatement of cocaine seeking in rats.
分子量

3289.95

Formula

C150H246N52O32
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

TAT-P4-(DATC5)2 相关分类

  • 摩尔计算器

  • 稀释计算器

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× = ×
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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

TAT-P4-(DATC5)2OthersPICK1proteininteractingwithCkinase-1PDZInhibitorinhibitorinhibit

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