2. NF-κB
  3. IKK
  4. TBK1/IKKε-IN-5

TBK1/IKKε-IN-5 (compound 1) 是一种口服有效的 TBK1 和 IKKε 的双重抑制剂，其 IC50 值分别为 1 nM 和 5.6 nM。TBK1/IKKε-IN-5 能增强对 PD-1 的阻断反应，与 anti-PD-L1 联用时能诱导大鼠的免疫记忆。TBK1/IKKε-IN-5 可用于癌症，尤其是肿瘤免疫的研究。

MCE 的所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务

TBK1/IKKε-IN-5 Chemical Structure

TBK1/IKKε-IN-5 Chemical Structure

CAS No. : 1893397-65-3

1.  客户无需承担相应的运输费用。

2.  同一机构（单位）同一产品试用装仅限申领一次，同一机构（单位）一年内

     可免费申领三个不同产品的试用装。

3.  试用装只面向终端客户。

规格 价格 是否有货 数量
1 mg ￥1561
In-stock
5 mg ￥3280
In-stock
10 mg ￥4600
In-stock
25 mg 现货 询价
50 mg   询价  
100 mg   询价  

* Please select Quantity before adding items.

Customer Review

TBK1/IKKε-IN-5 相关抗体

Top Publications Citing Use of Products

查看 IKK 亚型特异性产品:

查看所有亚型
IKK-α IKK-β IKK IKKε TBK1

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

TBK1/IKKε-IN-5 (compound 1) is an orally active TBK1 and IKKε dual inhibitor, with IC50 values of 1 and 5.6 nM, respectively. TBK1/IKKε-IN-5 enhances the blockade response to PD-1 and induces immune memory in rats when combines with anti-PD-L1. TBK1/IKKε-IN-5 can be used in cancer research, especially in tumour immunity[1].

IC50 & Target

IC50: 1 nM (TBK1), 5.6 nM (IKKε)[1].
体外研究
(In Vitro)

TBK1/IKKε-IN-5 (0.001-10 µM; 24 or 96 h) promotess secretion of IL-2 and IFN-γ in purified CD4+ and CD8+ T cells and IL-2 in Jurkat human T-cell leukemia cells[1].
TBK1/IKKε-IN-5 effectively blocks immune suppressive cytokine elaboration by CT26 cell line spheroids, without cytotoxic effects[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

TBK1/IKKε-IN-5 相关抗体:

Cell Viability Assay[1]

Cell Line: CD4+ and CD8+ T cells, Jurkat T cell leukemia cells
Concentration: 0.001-10 µM
Incubation Time: 24 h (for IL-2); 96 h(for IFN-γ)
Result: Enhanced secretion of IL-2 and IFN-γ.
体内研究
(In Vivo)

TBK1/IKKε-IN-5 (40 mg/kg; p.o.; single daily for 26 days) shows good antitumor activity and prolongs survival, as well as induces immunologic memory of CT26 cells in mice when combines with anti-PD-L1[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Female Balb/c mice (11 to 12-week-old; bearing CT26 tumors)[1].
Dosage: 40 mg/kg
Administration: Oral gavage; single daily for 26 days (combine with anti-PD-L1).
Result: Exhibited greater tumor control and longer survival when combined with anti-PD-L1 than used alone of both agents
Induced immunologic memory of CT26 cells in mice when combined with anti-PD-L1.
分子量

513.59

Formula

C28H31N7O3
CAS 号
性状

固体

颜色

Light yellow to yellow

运输条件

Room temperature in continental US; may vary elsewhere.
储存方式
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 2 years
-20°C 1 year
溶解性数据
细胞实验： 

DMSO 中的溶解度 : 7.81 mg/mL (15.21 mM; 超声助溶; 吸湿的 DMSO 对产品的溶解度有显著影响，请使用新开封的 DMSO)

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 1.9471 mL 9.7354 mL 19.4708 mL
5 mM 0.3894 mL 1.9471 mL 3.8942 mL
查看完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 2 years; -20°C, 1 year。-80°C储存时，请在2年内使用， -20°C储存时，请在1年内使用。

  • 摩尔计算器

  • 稀释计算器

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量
=
浓度
×
体积
×
分子量 *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start)

C1

×
体积 (start)

V1

=
浓度 (final)

C2

×
体积 (final)

V2

动物溶解方案计算器
请输入动物实验的基本信息：

给药剂量

mg/kg

动物的平均体重

g

每只动物的给药体积

μL

动物数量

只
由于实验过程有损耗，建议您多配一只动物的量
计算结果
工作液所需浓度 : mg/mL
纯度 & 产品资料

纯度: 99.58%

COA (190 KB) LCMS (266 KB)

产品使用指南 (1538 KB)
参考文献

TBK1/IKKε-IN-5 相关分类

完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 2 years; -20°C, 1 year。-80°C储存时，请在2年内使用， -20°C储存时，请在1年内使用。

可选溶剂 浓度 溶剂体积 质量 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 1.9471 mL 9.7354 mL 19.4708 mL 48.6770 mL
5 mM 0.3894 mL 1.9471 mL 3.8942 mL 9.7354 mL
10 mM 0.1947 mL 0.9735 mL 1.9471 mL 4.8677 mL
15 mM 0.1298 mL 0.6490 mL 1.2981 mL 3.2451 mL
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

TBK1/IKKε-IN-51893397-65-3IKKIκB kinaseI kappa B kinaseCT26CD4+CD8+ T cellsIL-2IFN-γCT26 tumorPD-L1combined immunizationInhibitorinhibitorinhibit

您最近查看的产品:

Your information is safe with us. * Required Fields.

   产品名称：

  

* 需求量：

* 客户姓名：

 

* Email：

* 电话：

 

* 公司或机构名称：

   留言给我们：

Bulk Inquiry

Inquiry Information

产品名称：
TBK1/IKKε-IN-5
目录号：
HY-128679
需求量：

Request for HNMR Report

Please fill out this form to request the QC report. We will send it to your Email address shortly.

Your information is safe with us. * Required Fields.

   产品名称：

  

* Lot #：

* 客户姓名：

 

* Email：

   电话：

 

* 部门：

* 公司或机构名称：

 

   留言给我们：

Request for HNMR Report

We have received your request and will respond to you as soon as possible.

嗨！很高兴为您提供帮助！

尊敬的 MCE 客户您好，
请您选择所在区域，我们将转接对应客服为您服务！

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z

热 A B C F G H J L N Q S T X Y Z