2. Antibody-drug Conjugate/ADC Related PROTAC
  3. ADC Linker PROTAC Linkers
  4. TCO-PEG12-NHS ester

TCO-PEG12-NHS ester 

目录号: HY-141170 纯度: ≥95.0%
COA 产品使用指南

摩尔计算器

TCO-PEG12-NHS ester 是一种 PROTAC 连接桥，属于 PEG 类。TCO-PEG12-NHS ester 可用于合成一系列 PROTAC 分子。TCO-PEG12-NHS ester 是一种可降解 (cleavable) 的 ADC 连接桥，用于抗体活性分子结合物 (ADCs) 的合成。

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TCO-PEG12-NHS ester Chemical Structure

TCO-PEG12-NHS ester Chemical Structure

CAS No. : 2185016-39-9

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规格 价格 是否有货 数量
5 mg ￥2500
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10 mg ￥3700
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TCO-PEG12-NHS ester 相关抗体

Top Publications Citing Use of Products

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PEG Linkers Alkyl-Chain Linkers Alkyl/ether Linkers

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

TCO-PEG12-NHS ester is a PEG-based PROTAC linker can be used in the synthesis of PROTACs. TCO-PEG12-NHS ester is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs)[1].

IC50 & Target[1]

Cleavable Linker

 

PEGs

 

体外研究
(In Vitro)

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.
ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker.

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

TCO-PEG12-NHS ester 相关抗体:
分子量

866.99

Formula

C40H70N2O18
CAS 号
性状

液体（密度：1.20±0.1 g/cm3）

颜色

Colorless to light yellow

运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

-20°C, sealed storage, away from moisture and light

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

纯度 & 产品资料

纯度: ≥95.0%

COA (292 KB) HNMR (305 KB) MS (74 KB)

产品使用指南 (1538 KB)
参考文献

TCO-PEG12-NHS ester 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

TCO-PEG12-NHS ester2185016-39-9ADC LinkerPROTAC LinkersAntibody-drug conjugates linkercleavableADCantibody-drugconjugatesInhibitorinhibitorinhibit

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产品名称：
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目录号：
HY-141170
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