2. Stem Cell/Wnt
  3. YAP
  4. TEAD-IN-11

TEAD-IN-11 (compound 38) 对 TEAD1 (IC50=8.7 nM)，TEAD2(IC50=3.4 nM)，TEAD3 (IC50=5.6 nM) 均有较好的抑制作用，作为共价抑制剂，TEAD-IN-11 对 TEAD1-3 具有良好的选择性活性。TEAD-IN-11 可以用于癌症研究.

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TEAD-IN-11 Chemical Structure

TEAD-IN-11 Chemical Structure

CAS No. : 3032196-88-3

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TEAD-IN-11 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

TEAD-IN-11 (compound 38) has a good inhibitory effect on TEAD1 (IC50=8.7 nM), TEAD2 (IC50=3.4 nM), TEAD3 (IC50=5.6 nnM). TEAD-IN-11 has good selective activity against TEAD1-3 as a covalent inhibitor. TEAD-IN-11 can be used for cancer research[1].

IC50 & Target

TEAD1

8.7 nM (IC50)

TEAD2

3.4 nM (IC50)

TEAD3

5.6 nM (IC50)

体外研究
(In Vitro)

TEAD-IN-11 对 MCF-7 报告基因试验有较好的抑制作用 (IC50≤10 nM) [1]。
TEAD-IN-11 对 TEAD1 和 TEAD2 具有很好的选择性，在 HEK293T 细胞中分别有 93% 和 95% 的抑制效果[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

TEAD-IN-11 相关抗体:

Cell Viability Assay[1]

Cell Line: NCl-H226 and H2052 cell lines
Concentration:
Incubation Time: 6 days
Result: The inhibitory effect of H2052 cell line (IC50≤100 nM) as well as that of NCl-H226 cell line (IC50:≤100 nM).

Cell Proliferation Assay[1]

Cell Line: NCl-H226 and H2052 cell lines
Concentration:
Incubation Time: 7 days
Result: The inhibition rate of anti-proliferation of both cell lines was greater than 75%.
分子量

293.28

Formula

C16H14F3NO
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

TEAD-IN-11 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

TEAD-IN-113032196-88-3YAPYes-associated proteinTEADcovalent inhibitordrughunterNCl-H226 and H2052 cell linesInhibitorinhibitorinhibit

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目录号：
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