2. Cell Cycle/DNA Damage Cytoskeleton
  3. Kinesin
  4. Terpendole E

Terpendole E 是有丝分裂驱动蛋白 Eg5 的抑制剂。Terpendole E 抑制人 Eg5 的运动和微管刺激的 ATPase 活性。Terpendole E 诱导 M 期单星状纺锤体的形成。

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Terpendole E Chemical Structure

Terpendole E Chemical Structure

CAS No. : 167427-23-8

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Terpendole E 相关抗体

Top Publications Citing Use of Products

查看 Kinesin 亚型特异性产品:

查看所有亚型
Kinesin-5/Eg5/KSP Kinesin-6 Kinesin-7/CENP-E Kinesin-12 Kinesin-14

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Terpendole E is a mitotic kinesin Eg5 inhibitor. Terpendole E inhibits both motor and microtubule-stimulated ATPase activities of human Eg5. Terpendole E induces formation of a monoastral spindle in M phase[1].

IC50 & Target[1]

Eg5

 

细胞效力
(Cellular Effect)
Cell Line Type Value Description References
A2780 IC50
31.1 μM
Compound: 9
Cytotoxicity against human A2780 cells assessed as growth inhibition after 48 hrs by MTT assay
Cytotoxicity against human A2780 cells assessed as growth inhibition after 48 hrs by MTT assay
[PMID: 26356746]
A549 IC50
18.82 μM
Compound: 9
Cytotoxicity against human A549 cells assessed as growth inhibition after 48 hrs by MTT assay
Cytotoxicity against human A549 cells assessed as growth inhibition after 48 hrs by MTT assay
[PMID: 26356746]
HeLa IC50
12.1 μM
Compound: 10
Cytotoxicity against human HeLa cells assessed as reduction in cell viability after 48 hrs by SF-based cell counting method
Cytotoxicity against human HeLa cells assessed as reduction in cell viability after 48 hrs by SF-based cell counting method
[PMID: 27865702]
K562 IC50
38.7 μM
Compound: 9
Cytotoxicity against human K562 cells assessed as growth inhibition after 48 hrs by MTT assay
Cytotoxicity against human K562 cells assessed as growth inhibition after 48 hrs by MTT assay
[PMID: 26356746]
MDA-MB-231 IC50
39.22 μM
Compound: 9
Cytotoxicity against human MDA-MB-231 cells assessed as growth inhibition after 48 hrs by MTT assay
Cytotoxicity against human MDA-MB-231 cells assessed as growth inhibition after 48 hrs by MTT assay
[PMID: 26356746]
分子量

437.61

Formula

C28H39NO3
CAS 号
结构分类
初始来源

soil-isolated fungus
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Terpendole E 相关分类

  • 摩尔计算器

  • 稀释计算器

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Terpendole E167427-23-8Kinesinmitotic kinesin Eg5monoastral spindleATPasInhibitorinhibitorinhibit

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目录号：
HY-119407
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