2. Membrane Transporter/Ion Channel Neuronal Signaling
  3. GABA Receptor
  4. TG 41

TG 41 是 GABAA 受体 的正调节剂。TG 41 增强 GABA 和 Flunitrazepam 与大鼠大脑皮层膜的结合

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TG 41 Chemical Structure

TG 41 Chemical Structure

CAS No. : 850339-33-2

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TG 41 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

TG 41 is positive modulator of GABAA receptor. TG 41 enhances the binding both of GABA and of Flunitrazepam to rat cerebral cortical membranes[1].

体外研究
(In Vitro)

TG41 (0.001-10 µM) 增加特异性 [3H]GABA 与大鼠大脑皮质膜的结合[1]。
TG41 (0.001-10 µM) 增加表达重组 α1β2γ2L GABAA 受体的蟾蜍卵母细胞中的内向 Cl- 电流[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

TG 41 相关抗体:
体内研究
(In Vivo)

TG 41 (5mg/kg, i.v.) 引起大鼠催眠[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Rats[1]
Dosage: 5 mg/kg
Administration: i.v.
Result: Induced loss of the righting reflex within 8 s and for a duration of 28 min.
分子量

440.12

Formula

C18H13BrCl2N2O2
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

TG 41 相关分类

  • 摩尔计算器

  • 稀释计算器

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

TG 41850339-33-2TG41TG-41GABA ReceptorGamma-aminobutyric acid Receptorγ-Aminobutyric acid ReceptorGABAX. laevishypnosisrat cerebral corticalInhibitorinhibitorinhibit

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