2. PROTAC Autophagy Apoptosis
  3. E3 Ligase Ligand-Linker Conjugates Autophagy Apoptosis
  4. Thalidomide-O-amido-C6-NH2 hydrochloride

Thalidomide-O-amido-C6-NH2 hydrochloride 

目录号: HY-112618B 纯度: 99.32%
COA 产品使用指南

摩尔计算器

Thalidomide-O-amido-C6-NH2 hydrochloride 是一种合成的 E3 连接酶配体-linker 偶联物，包含基于 Thalidomide 的 cereblon 配体和 1 个 linker。可用于合成 PROTAC 分子。

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Thalidomide-O-amido-C6-NH2 hydrochloride Chemical Structure

Thalidomide-O-amido-C6-NH2 hydrochloride Chemical Structure

CAS No. : 2376990-31-5

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规格 价格 是否有货 数量
25 mg ￥1105
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50 mg ￥2050
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100 mg ￥3697
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Other Forms of Thalidomide-O-amido-C6-NH2 hydrochloride:

Thalidomide-O-amido-C6-NH2 hydrochloride 相关抗体

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查看 E3 Ligase Ligand-Linker Conjugates 亚型特异性产品:

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von Hippel-Lindau (VHL) MDM2 Cereblon cIAP1 Aryl Hydrocarbon Receptor TRIM21

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Thalidomide-O-amido-C6-NH2 hydrochloride, a synthesized E3 ligase ligand-linker conjugate that incorporates the Thalidomide based cereblon ligand and a linker, can be used in the synthesis of PROTACs[1].

IC50 & Target

Cereblon

 

体外研究
(In Vitro)

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Thalidomide-O-amido-C6-NH2 hydrochloride 相关抗体:
分子量

466.92

Formula

C21H27ClN4O6
CAS 号
性状

固体

颜色

White to off-white

运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

4°C, sealed storage, away from moisture and light

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

纯度 & 产品资料
参考文献

Thalidomide-O-amido-C6-NH2 hydrochloride 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Thalidomide-O-amido-C6-NH22376990-31-5E3 Ligase Ligand-Linker ConjugatesAutophagyApoptosisInhibitorinhibitorinhibit

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目录号：
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