Thiamethoxam-d₃  (Synonyms: 噻虫嗪-d₃)

Thiamethoxam-d₃ is the deuterium labeled Thiamethoxam[1]. Thiamethoxam is a broad spectrum neonicotinoid insecticide[2][3].

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs^[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

294.73

C₈H₇D₃ClN₅O₃S

1294048-82-0

153719-23-4

固体

White to off-white

噻虫嗪-d₃

Room temperature in continental US; may vary elsewhere.

-20°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

• [1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53(2):211-216.  [Content Brief]

  [2]. Lobson C, et al. Fate of thiamethoxam in mesocosms and response of the zooplankton community. Sci Total Environ. 2018 Oct 1;637-638:1150-1157.  [Content Brief]

  [3]. Ludicke JC, et al. Thiamethoxam impairs honey bee visual learning, alters decision times, and increases abnormal behaviors. Ecotoxicol Environ Saf. 2020 Apr 15193:110367.  [Content Brief]