2. Metabolic Enzyme/Protease
  3. Endogenous Metabolite
  4. Thioetheramide-PC

Thioetheramide-PC  (Synonyms: 1-Palmitylthio-2-palmitoylamido-1,2-dideoxy-sn-glycero-3-phosphorylcholine)

目录号: HY-133233
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摩尔计算器

Thioetheramide-PC (1-Palmitylthio-2-palmitoylamido-1,2-dideoxy-sn-glycero-3-phosphorylcholine) 是一种结构改良的磷脂，可作为分泌性磷脂酶 A2 (sPLA2) 的竞争性可逆抑制剂。Thioetheramide-PC (1-Palmitylthio-2-palmitoylamido-1,2-dideoxy-sn-glycero-3-phosphorylcholine) 的 IC50 值为 2 μM，底物浓度为 0.5 mM。除了与 sPLA2 的催化位点结合外，Thioetheramide-PC (1-Palmitylthio-2-palmitoylamido-1,2-dideoxy-sn-glycero-3-phosphorylcholine) 还与该酶的激活位点结合。Thioetheramide-PC (1-Palmitylthio-2-palmitoylamido-1,2-dideoxy-sn-glycero-3-phosphorylcholine) 与激活位点的结合比与催化位点的结合更紧密。这种双重相互作用的结果 是，在低浓度下，Thioetheramide-PC (1-Palmitylthio-2-palmitoylamido-1,2-dideoxy-sn-glycero-3-phosphorylcholine) 可能会激活磷脂酶活性，而不 是抑制它。

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Thioetheramide-PC Chemical Structure

Thioetheramide-PC Chemical Structure

CAS No. : 116457-99-9

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Thioetheramide-PC 相关抗体

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  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Thioetheramide-PC is a structurally modified phospholipid that functions as a competitive, reversible inhibitor of secretory phospholipase A2 (sPLA2). The IC50 value for thioetheramide-PC is 2 μM at a substrate concentration of 0.5 mM.1 In addition to binding to the catalytic site of sPLA2, thioetheramide-PC also binds to the activator site of this enzyme. The binding of thioetheramide-PC to the activator site is tighter than its binding to the catalytic site. The result of this dual interaction is that at low concentrations thioetheramide-PC may activate phospholipase activity rather than inhibiting it.

分子量

735.14

Formula

C40H83N2O5PS
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Thioetheramide-PC 相关分类

  • 摩尔计算器

  • 稀释计算器

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  • Do most proteins show cross-species activity?

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Keywords:

Thioetheramide-PC116457-99-91-Palmitylthio-2-palmitoylamido-1,2-dideoxy-sn-glycero-3-phosphorylcholineEndogenous MetaboliteInhibitorinhibitorinhibit

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