2. Neuronal Signaling
  3. Amyloid-β
  4. THK-523

THK-523 在体内外对 tau 具有高亲和力和选择性。18F-THK-523 是一种有效的 tau 成像放射性示踪剂。18F-THK-523 是一种有效的体内 tau 成像配体，可用于研究阿尔茨海默症。

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THK-523 Chemical Structure

THK-523 Chemical Structure

CAS No. : 1573029-17-0

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THK-523 相关抗体

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  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

THK-523 has demonstrated its high affinity and selectivity for tau pathology both in vitro and in vivo. 18F-THK523 is a potent tau imaging radiotracer. 18F-THK523 is a potent in vivo tau imaging ligand for Alzheimer's disease[1].

体内研究
(In Vivo)

THK-523 crosses the blood–brain barrier in mice and the in vivo retention rate in the brain of Tau transgenic mice increased[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Brain of tau transgenic mice[1]
Dosage: 0.35 μg/kg
Administration: Intravenous injection;25-30 mins
Result: Overexpressed Tau in brain.
分子量

282.31

Formula

C17H15FN2O
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

THK-523 相关分类

  • 摩尔计算器

  • 稀释计算器

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

THK-5231573029-17-0THK523THK 523Amyloid-ββ-amyloid peptideAβAbetatau pathologytau imaging radiotracerAlzheimer diseaseInhibitorinhibitorinhibit

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