2. Anti-infection
  3. Reverse Transcriptase HIV
  4. Tivirapine

Tivirapine  (Synonyms: R86183; TIBO R 86183)

目录号: HY-106918
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Tivirapine (R86183) 是一种非核苷类 HIV-1 RT 抑制剂，能够对抗 HIV-1 引发的细胞病理效应，EC50 值为 4 nM。Tivirapine 能够抑制 HIV-1 RT 的 Yl8lC 突变体。

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Tivirapine Chemical Structure

Tivirapine Chemical Structure

CAS No. : 137332-54-8

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Tivirapine 相关抗体

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HIV HIV-1 HIV-2

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Tivirapine (R86183) is a nonnucleoside HIV-1 RT inhibitor against HIV-1-induced cytopathic effects with an EC50 value of 4 nM. Tivirapine inhibits the Yl8lC mutant of HIV-1 RT[1].

细胞效力
(Cellular Effect)
Cell Line Type Value Description References
C8166 EC50
0.03 μM
Compound: 8-ClTIBO
Antiviral activity against HIV1 3B infected human C8166 cells assessed as inhibition of syncytia formation by p24 antigen based assay
Antiviral activity against HIV1 3B infected human C8166 cells assessed as inhibition of syncytia formation by p24 antigen based assay
[PMID: 19170521]
C8166 CC50
50 μM
Compound: 8-CITIBO
Cytotoxicity against C8166 cells by MTT assay
Cytotoxicity against C8166 cells by MTT assay
[PMID: 16279773]
MT2 IC50
> 100 nM
Compound: 2, 8-Cl-TIBO
Cytotoxicity against human MT2 cells after 5 days by MTT assay
Cytotoxicity against human MT2 cells after 5 days by MTT assay
[PMID: 23380374]
MT2 EC50
14 nM
Compound: 2, 8-Cl-TIBO
Antiviral activity against HIV-1 infected un MT2 cells assessed as virus-induced cytopathicity after 5 days by MTT assay
Antiviral activity against HIV-1 infected un MT2 cells assessed as virus-induced cytopathicity after 5 days by MTT assay
[PMID: 23380374]
分子量

321.87

Formula

C16H20ClN3S
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Tivirapine 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Tivirapine137332-54-8R86183 TIBO R 86183R 86183R-86183TIBO R86183TIBO R 86183TIBO R-86183Reverse TranscriptaseHIVHuman immunodeficiency virusHIV-1 RTcytopathic effectYl8lC mutantInhibitorinhibitorinhibit

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