2. Apoptosis
  3. Apoptosis
  4. TJ08

TJ08 是一种 1,2,5-三取代苯并咪唑衍生物，可有效诱导 G1/S 期阻滞并促进多种癌细胞凋亡。TJ08 是一种抗癌剂。

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TJ08 Chemical Structure

TJ08 Chemical Structure

CAS No. : 2924274-19-9

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TJ08 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

TJ08, a 1,2,5-trisubstituted benzimidazole derivative, efficiently induces G1/S phase arrest and promotes apoptosis in various cancer cells. TJ08 is an anticancer agent[1].

体外研究
(In Vitro)

TJ08 (0-20 μM; 48 和 72 小时) 对多种癌细胞系具有抗增殖作用，IC50 范围为 1.88-3.82 μM[1]。
TJ08 (1-10 μM; 24 小时) 通过改变线粒体膜电位引发细胞凋亡[1]。
TJ08 (1-10 μM; 24 小时) 引发 S 期阻滞并阻止癌细胞进展[1]。
TJ08 (1-10 μM; 24 小时) 引起裂解半胱天冬酶的上调和抗凋亡 BCl2 蛋白的下调[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

TJ08 相关抗体:

Cell Proliferation Assay[1]

Cell Line: Human leukemic cancer cells (Jurkat, K562, and Molt4), human cervical cancer cells (HeLa), human colorectal carcinoma cells (HCT116), and human pancreatic ductal adenocarcinoma (MIAPaCa-2)
Concentration: 0-20 μM
Incubation Time: 48 and 72 h
Result: Showed effective against various cells with IC50s of 1.88 μM, 1.89 μM, 2.05 μM, 2.11 μM, 3.04 μM, and 3.82 μM against Jurkat, K562, MOLT-4, HeLa, HCT116, and MIA PaCa-2 cancer cell lines, respectively.

Apoptosis Analysis[1]

Cell Line: Jurkat cells
Concentration: 1, 5, 10 μM
Incubation Time: 24 h
Result: Induced cell death by apoptosis, not by necrosis, in a concentration-dependent manner.

Cell Cycle Analysis[1]

Cell Line: Jurkat cells
Concentration: 1, 5, 10 μM
Incubation Time: 24 h
Result: Cauesd the accumulation of cells at the S phase in a concentration-dependent manner followed by increased accumulation of a sub-G1 population of cells.

Western Blot Analysis[1]

Cell Line: Jurkat cells
Concentration: 1, 5, 10 μM
Incubation Time: 24 h
Result: Caused the upregulation of cleaved caspase and downregulation of antiapoptotic BCl2 proteins.
分子量

405.38

Formula

C22H16FN3O4
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

TJ08 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

TJ082924274-19-9TJ 08TJ-08Apoptosis1,2,5-trisubstituted benzimidazoleG1/S phaseanticancerInhibitorinhibitorinhibit

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产品名称：
TJ08
目录号：
HY-152135
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