2. Immunology/Inflammation
  3. Toll-like Receptor (TLR)
  4. TLR7/8 agonist 7

TLR7/8 agonist 7 (compound 10) 是一种 TLR7/8 激动剂。TLR7/8 agonist 7 可激活多种免疫细胞，可用于合成抗体-免疫刺激偶联物 ISAC 分子。TLR7/8 agonist 7 可用于免疫的研究。

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TLR7/8 agonist 7 Chemical Structure

TLR7/8 agonist 7 Chemical Structure

CAS No. : 2567953-47-1

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TLR7/8 agonist 7 相关抗体

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TLR3 TLR8 TLR9 TLR2 TLR4 TLR7 TLR1 TLR6

  • 生物活性

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生物活性

TLR7/8 agonist 7 (compound 10) is a TLR7/8 agonist. TLR7/8 agonist 7 activates a variety of immune cells and it can be used to synthesize immune stimulating antibody conjugate (ISAC) molecules. TLR7/8 agonist 7 can be used for the research of immunity[1].

体外研究
(In Vitro)

TLR7/8 agonist 7 (compound 10) (0-1 μΜ; 24 h) is a TLR7 agonist and shows selectivity to TLR7[1].
TLR7/8 agonist 7 (compound 10) (0-1 μΜ; 120 h) shows no cytotoxicity to KB cells[1].
TLR7/8 agonist 7 (compound 10) (0.01, 0.1, 1, 10, 100 and 1000 nM; 48 h) induces immune cells activation[1].
TLR7/8 agonist 7 (compound 10) (0.1, 1, 10, 100 and 1000 nM; 24-48 h) induces cytokine release[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

TLR7/8 agonist 7 相关抗体:

Cell Viability Assay[1]

Cell Line: HEK293-humanTLR7 (hTLR7), HEK293-mouseTLR7 (mTLR7) and HEK293-humanTLR8 (hTLR8) cell lines
Concentration: 0-1000 nM
Incubation Time: 24 h
Result: Showed selectivity to TLR7 and TLR8 as an agonist with EC50s of 1.5, 341.7 and 3.7nM in hTLR7, hTLR8 and mTLR7, respectively at 24 h.

Cell Cytotoxicity Assay[1]

Cell Line: KB cells
Concentration: 0-1000 nM
Incubation Time: 120 h
Result: Exhibited no cytotoxicity to KB cells though until concentration up to 1 μΜ.

Cell Viability Assay[1]

Cell Line: Human peripheral blood mononuclear cells (PBMCs), cyno PBMCs and mouse splenocytes
Concentration: 0.01, 0.1, 1, 10, 100 and 1000 nM
Incubation Time: 48 h
Result: Activated immune cells (monocyte, B cell, and DCs) in human PBMCs, cyno PBMCs and mouse splenocytes.

Cell Viability Assay[1]

Cell Line: Human peripheral blood mononuclear cells (PBMCs), cyno PBMCs and mouse splenocytes
Concentration: 0.1, 1, 10, 100 and 1000 nM
Incubation Time: 24 and 48 h
Result: Stimulated IL-6 , MCP-I , and ILlRa release from human PBMCs, IL-6 and MCP-I release from cyno PBMCs, as well as IL-6 , MCP-I , TNFa and IP-10 release from mouse splenocytes.
分子量

479.62

Formula

C26H37N7O2
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

TLR7/8 agonist 7 相关分类

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

TLR7/8 agonist 72567953-47-1Toll-like Receptor (TLR)agonistISACimmune cellTLRInhibitorinhibitorinhibit

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