2. Apoptosis NF-κB
  3. TNF Receptor NF-κB
  4. TNF-α-IN-18

TNF-α-IN-18 (Compound 61) 是 TNF-α 的抑制剂 (IC50 为 1.8 μM)，通过阻断 NF-kB 从细胞质迁移到细胞核来抑制 TNF 信号通路。TNF-α-IN-18 对小鼠成纤维细胞 LM 表现出轻微的细胞毒性，CC50 >50 μM。TNF-α-IN-18 可改善小鼠模型中 TNF 或 Lipopolysaccharide (HY-D1056) 诱发的脓毒症。TNF-α-IN-18 可保护小鼠免受类风湿性关节炎。

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TNF-α-IN-18 Chemical Structure

TNF-α-IN-18 Chemical Structure

CAS No. : 1272322-42-5

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规格 价格 是否有货 数量
5 mg ￥800
1 - 2 周
10 mg ￥1250
1 - 2 周
25 mg ￥2500
1 - 2 周
50 mg ￥4000
1 - 2 周
100 mg 现货 1 - 2 周
200 mg   询价  
500 mg   询价  

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TNF-α-IN-18 相关抗体

Top Publications Citing Use of Products

查看 TNF Receptor 亚型特异性产品:

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TNFRSF1A/CD120a TNFRSF5/CD40 TNFRSF6/Fas/CD95 TNFRSF8/CD30 TNFRSF9/4-1BB/CD137 TNFRSF16/NGF Receptor/CD271 TNFRSF18/GITR/CD357

查看 NF-κB 亚型特异性产品:

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NF-κB NF-κB1/p50 RelA/p65 RelB c-Rel

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

TNF-α-IN-18 (Compound 61) is an inhibitor for TNF-α (IC50 of 1.8 μM), that inhibits TNF signaling pathway through block of NF-kB migration from cytoplasm to nucleus. TNF-α-IN-18 exhibits slight cytotoxicity to mouse fibroblast LM cell, with a CC50 >50 μM. TNF-α-IN-18 ameliorates the TNF- or Lipopolysaccharide (HY-D1056)-induced sepsis in mouse models. TNF-α-IN-18 protects mice from rheumatoid arthritis[1].

分子量

336.67

Formula

C16H7ClF2O4
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

TNF-α-IN-18 相关分类

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

TNF-α-IN-181272322-42-5TNF ReceptorNF-κBTumor Necrosis Factor ReceptorTNFRNuclear factor-κBNuclear factor-kappaBseptic lethality modelrheumatoid arthritisinflammatory bowel diseaseIBDacute kidney injuryCIA mouseBALB/c mouseC57BL/6 J mouseInhibitorinhibitorinhibit

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