2. Apoptosis Metabolic Enzyme/Protease Immunology/Inflammation NF-κB
  3. Apoptosis Reactive Oxygen Species
  4. Tomentosin

Tomentosin 是一种抗炎的倍半萜内酯，可以从里海旋覆花中分离出来。Tomentosin 诱导胰腺癌细胞的凋亡并抑制增殖、迁移和侵袭。

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Tomentosin Chemical Structure

Tomentosin Chemical Structure

CAS No. : 33649-15-9

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Tomentosin 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Tomentosin is a antiphlogistic sesquiterpene lactone that can be isolated from Inula falconeri.Tomentosin induces apoptosis and inhibits proliferation, migration and invasion of pancreatic cancer cells[1].

细胞效力
(Cellular Effect)
Cell Line Type Value Description References
HT-29 IC50
56.5 μM
Compound: 9
Cytostatic activity against human HT-29 cells incubated for 72 hrs by alamar blue reagent based resazurin metabolism assay
Cytostatic activity against human HT-29 cells incubated for 72 hrs by alamar blue reagent based resazurin metabolism assay
[PMID: 26218649]
MCF7 IC50
> 50 μg/mL
Compound: 17
Antiproliferative activity against human MCF7 cells after 48 hrs by MTT assay
Antiproliferative activity against human MCF7 cells after 48 hrs by MTT assay
[PMID: 21109433]
MCF7 IC50
26.6 μM
Compound: 9
Cytostatic activity against human MCF7 cells incubated for 6 days by alamar blue reagent based resazurin metabolism assay
Cytostatic activity against human MCF7 cells incubated for 6 days by alamar blue reagent based resazurin metabolism assay
[PMID: 26218649]
RAW264.7 IC50
15.7 μM
Compound: 9
Anti-inflammatory activity in mouse RAW264.7 cells assessed as inhibition of LPS-induced thromboxane B2 production incubated for 48 hrs by ELISA method
Anti-inflammatory activity in mouse RAW264.7 cells assessed as inhibition of LPS-induced thromboxane B2 production incubated for 48 hrs by ELISA method
[PMID: 26218649]
RAW264.7 IC50
2 μM
Compound: 11
Inhibition of LPS-induced NO production in mouse RAW264.7 cells incubated for 24 hrs by Griess reagent based assay
Inhibition of LPS-induced NO production in mouse RAW264.7 cells incubated for 24 hrs by Griess reagent based assay
[PMID: 27276091]
RAW264.7 IC50
7.14 μM
Compound: 32
Antiinflammatory activity in mouse RAW264.7 cells assessed as inhibition of LPS-induced NO production pretreated for 30 mins before LPS challenge measured 24 hrs after LPS challenge by Griess reaction method
Antiinflammatory activity in mouse RAW264.7 cells assessed as inhibition of LPS-induced NO production pretreated for 30 mins before LPS challenge measured 24 hrs after LPS challenge by Griess reaction method
[PMID: 21924800]
RAW264.7 IC50
7.3 μM
Compound: 9
Anti-inflammatory activity in mouse RAW264.7 cells assessed as inhibition of LPS-induced prostaglandin E2 production incubated for 48 hrs by ELISA method
Anti-inflammatory activity in mouse RAW264.7 cells assessed as inhibition of LPS-induced prostaglandin E2 production incubated for 48 hrs by ELISA method
[PMID: 26218649]
RAW264.7 IC50
9.15 μM
Compound: 12
Inhibition of LPS-induced NO production in mouse RAW264.7 cells measured after 24 hrs
Inhibition of LPS-induced NO production in mouse RAW264.7 cells measured after 24 hrs
[PMID: 20515062]
分子量

248.32

Formula

C15H20O3
CAS 号
性状

固体

颜色

White to off-white

结构分类
初始来源
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

-20°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

纯度 & 产品资料
参考文献

Tomentosin 相关分类

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Tomentosin33649-15-9ApoptosisReactive Oxygen Speciesnatural productinvasionmigrationproliferationpancreaticlactoneInhibitorinhibitorinhibit

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