2. Cell Cycle/DNA Damage
  3. Topoisomerase
  4. Topoisomerase II inhibitor 4

Topoisomerase II inhibitor 4 (compound E17) 是一种有效的拓扑异构酶 II (Topoisomerase II) 抑制剂。Topoisomerase II inhibitor 4 具有抗肿瘤作用，引起 G2/M 期细胞周期阻滞，抑制癌细胞增殖并显示出细胞毒性。

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Topoisomerase II inhibitor 4 Chemical Structure

Topoisomerase II inhibitor 4 Chemical Structure

CAS No. : 2560590-49-8

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Topoisomerase II inhibitor 4 相关抗体

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Topoisomerase Topo I Topo II

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Topoisomerase II inhibitor 4 (compound E17) is a potent Topoisomerase II inhibitor. Topoisomerase II inhibitor 4 triggers G2/M cell cycle arrest and shows anti-tumor activity with strong cytotoxic and anti-proliferative effect[1].

IC50 & Target

Topoisomerase II

 

细胞效力
(Cellular Effect)
Cell Line Type Value Description References
HCT-116 IC50
0.4 μM
Compound: E17
Antiproliferative activity against human HCT-116 cells assessed as reduction in cell viability incubated for 72 hrs by SRB assay
Antiproliferative activity against human HCT-116 cells assessed as reduction in cell viability incubated for 72 hrs by SRB assay
[PMID: 33191085]
HeLa IC50
0.6 μM
Compound: E17
Antiproliferative activity against human HeLa cells assessed as reduction in cell viability incubated for 72 hrs by SRB assay
Antiproliferative activity against human HeLa cells assessed as reduction in cell viability incubated for 72 hrs by SRB assay
[PMID: 33191085]
SW480 IC50
0.3 μM
Compound: E17
Antiproliferative activity against human SW480 cells assessed as reduction in cell viability incubated for 72 hrs by SRB assay
Antiproliferative activity against human SW480 cells assessed as reduction in cell viability incubated for 72 hrs by SRB assay
[PMID: 33191085]
体外研究
(In Vitro)

Topoisomerase II inhibitor 4 (compound E17) inhibits cancer cells with IC50 values of 4.55 μM (MDA-MB-231), 6.61 μM (A549), 2.18 μM (KG1)[1].
Topoisomerase II inhibitor 4 (1 μM; 0-22 h) induces G2/M cell cycle arrest[2].
Topoisomerase II inhibitor 4 (5 μM; 4 h) inhibits topo II-mediated chromosomes condensation in CRC cells, while also (100 μM; 0.5, 1, 2 h) induces topo II–DNA complex accumulation without degradation of topo II[2].
Topoisomerase II inhibitor 4 (1 μM; 4 h) exerts anti-tumor activity without increasing gH2AX levels in HCT116, while no DNA damage and apoptosis as well [2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Topoisomerase II inhibitor 4 相关抗体:

Cell Migration Assay [2]

Cell Line: HCT116, and WI-38 cells
Concentration: 0.4, 0.6, 0.8, 1.0, 1.2 μM
Incubation Time: 0, 12, 24, 48 hours
Result: Resulted migration inhibition in HCT116 and SW480 cells.

Cell Viability Assay[2]

Cell Line: HCT116, and WI-38 cells
Concentration: 0.39, 0.78, 1.56, 3.12, 6.25, 12.5, 25 μM
Incubation Time: 72 hours
Result: Exerted anti-proliferative effect in a dose-dependent manner.
分子量

459.50

Formula

C25H25N5O4
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Topoisomerase II inhibitor 4 相关分类

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  • Do most proteins show cross-species activity?

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Keywords:

Topoisomerase II inhibitor 42560590-49-8Topoisomerase II inhibitor4Topoisomerase II inhibitor-4TopoisomeraseTopo IIα/β inhibitorN-substituted acridonecell cycle arrestcytotoxicanti-proliferativeHCT116SW480Inhibitorinhibitorinhibit

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