2. Cell Cycle/DNA Damage
  3. Topoisomerase
  4. Topoisomerase II inhibitor 4

Topoisomerase II inhibitor 4 (compound E17) 是一种有效的拓扑异构酶 II (Topoisomerase II) 抑制剂。Topoisomerase II inhibitor 4 具有抗肿瘤作用，引起 G2/M 期细胞周期阻滞，抑制癌细胞增殖并显示出细胞毒性。

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Topoisomerase II inhibitor 4 Chemical Structure

Topoisomerase II inhibitor 4 Chemical Structure

CAS No. : 2560590-49-8

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Topoisomerase II inhibitor 4 相关抗体

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Topoisomerase Topo I Topo II

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Topoisomerase II inhibitor 4 (compound E17) is a potent Topoisomerase II inhibitor. Topoisomerase II inhibitor 4 triggers G2/M cell cycle arrest and shows anti-tumor activity with strong cytotoxic and anti-proliferative effect[1].

IC50 & Target

Topoisomerase II

 

体外研究
(In Vitro)

Topoisomerase II inhibitor 4 (compound E17) inhibits cancer cells with IC50 values of 4.55 μM (MDA-MB-231), 6.61 μM (A549), 2.18 μM (KG1)[1].
Topoisomerase II inhibitor 4 (1 μM; 0-22 h) induces G2/M cell cycle arrest[2].
Topoisomerase II inhibitor 4 (5 μM; 4 h) inhibits topo II-mediated chromosomes condensation in CRC cells, while also (100 μM; 0.5, 1, 2 h) induces topo II–DNA complex accumulation without degradation of topo II[2].
Topoisomerase II inhibitor 4 (1 μM; 4 h) exerts anti-tumor activity without increasing gH2AX levels in HCT116, while no DNA damage and apoptosis as well [2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Topoisomerase II inhibitor 4 相关抗体:

Cell Migration Assay [2]

Cell Line: HCT116, and WI-38 cells
Concentration: 0.4, 0.6, 0.8, 1.0, 1.2 μM
Incubation Time: 0, 12, 24, 48 hours
Result: Resulted migration inhibition in HCT116 and SW480 cells.

Cell Viability Assay[2]

Cell Line: HCT116, and WI-38 cells
Concentration: 0.39, 0.78, 1.56, 3.12, 6.25, 12.5, 25 μM
Incubation Time: 72 hours
Result: Exerted anti-proliferative effect in a dose-dependent manner.
分子量

459.50

Formula

C25H25N5O4
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Topoisomerase II inhibitor 4 相关分类

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Topoisomerase II inhibitor 42560590-49-8Topoisomerase II inhibitor4Topoisomerase II inhibitor-4TopoisomeraseTopo IIα/β inhibitorN-substituted acridonecell cycle arrestcytotoxicanti-proliferativeHCT116SW480Inhibitorinhibitorinhibit

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目录号：
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