2. Cell Cycle/DNA Damage Apoptosis
  3. Topoisomerase Apoptosis
  4. Topoisomerase IIα-IN-5

Topoisomerase IIα-IN-5 是一种拓扑异构酶 II (topo II) α 催化抑制剂。Topoisomerase IIα-IN-5 插入 DNA 并与 DNA 小槽结合。Topoisomerase IIα-IN-5 表现出比 Etoposide (HY-13629) 更好的疗效和更小的遗传毒性。

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Topoisomerase IIα-IN-5 Chemical Structure

Topoisomerase IIα-IN-5 Chemical Structure

CAS No. : 3037545-23-3

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Topoisomerase IIα-IN-5 相关抗体

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Topoisomerase Topo I Topo II

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Topoisomerase IIα-IN-5 is a topoisomerase II (topo II) α catalytic inhibitor. Topoisomerase IIα-IN-5 intercalates into DNA and binds to the DNA minor groove. Topoisomerase IIα-IN-5 exhibits better efficacy and less genotoxicity than Etoposide (HY-13629)[1].

IC50 & Target[1]

topoisomerase II alpha

 

体外研究
(In Vitro)

Topoisomerase IIα-IN-5 (compound 6) (5 μM, 10 μM, and 20 μM; 10 d) inhibits colony formation of DU145 cells[1].
Topoisomerase IIα-IN-5 (1 μM and 10 μM; 72 h) shows antiproliferative against DU145 cells[1].
Topoisomerase IIα-IN-5 has cytotoxicity against DU145, HCT15, and T47D cells with IC50s of 0.13 μM, 9.25 μM, and 0.53 μM, respectively[1].
Topoisomerase IIα-IN-5 (200 μM) interacts with a DNA double helix[1].
Topoisomerase IIα-IN-5 (20 μM; 24 h) induces G2 cell cycle arrest and apoptosis in CRPC cells[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Topoisomerase IIα-IN-5 相关抗体:

Western Blot Analysis[1]

Cell Line: CRPC cells
Concentration: 0, 5, 10, and 20 μM
Incubation Time: 0, 8, 16, and 24 hours
Result: Increased the expression of both phosphorylated cdc25c and phosphorylated cdc2.

Apoptosis Analysis[1]

Cell Line: CRPC cells
Concentration: 0, 5, 10, and 20 μM
Incubation Time: 0, 8, 16, and 24 hours
Result: Induced cell cycle arrest at G2 phase.
Induced cell apoptosis.
分子量

438.52

Formula

C25H30N2O5
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Topoisomerase IIα-IN-5 相关分类

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Keywords:

Topoisomerase IIα-IN-53037545-23-3TopoisomeraseApoptosisInhibitorinhibitorinhibit

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产品名称：
Topoisomerase IIα-IN-5
目录号：
HY-152187
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