2. Stem Cell/Wnt Apoptosis
  3. Hedgehog Smo Gli Apoptosis
  4. TPB15

TPB15 是一种口服有效的 Hh (Hedgehog) 信号抑制剂。TPB15 显著诱导 MDA-MB-468 细胞周期阻滞和凋亡。TPB15 阻断 Smo (Smoothened) 转位到纤毛中，降低 Smo 蛋白和 mRNA 表达。TPB15 可抑制下游调控因子胶质瘤相关癌基因1 (Gli1) 的表达。TPB15 具有较好的抗肿瘤活性和较低的毒性。

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TPB15 Chemical Structure

TPB15 Chemical Structure

CAS No. : 2170347-69-8

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TPB15 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

TPB15 is an orally active and potent Hh (Hedgehog) signaling inhibitor. TPB15 markedly induces cell cycle arrest and apoptosis in MDA-MB-468 cells. TPB15 blocks Smo (Smoothened) translocation into the cilia and reduced Smo protein and mRNA expression. TPB15 inhibits the expression of the downstream regulatory factor glioma-associated oncogene 1 (Gli1). TPB15 shows good anti-tumor activity with low toxicity[1].

细胞效力
(Cellular Effect)
Cell Line Type Value Description References
A549 IC50
64.9 μM
Compound: TPB15
Antiproliferation activity against human A549 cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay
Antiproliferation activity against human A549 cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay
[PMID: 32690258]
AN3-CA IC50
44.5 μM
Compound: TPB15
Antiproliferation activity against human AN3CA cells assessed as reduction in cell viability incubated for 72 hr by MTT assay
Antiproliferation activity against human AN3CA cells assessed as reduction in cell viability incubated for 72 hr by MTT assay
[PMID: 32690258]
HeLa IC50
66.3 μM
Compound: TPB15
Antiproliferation activity against human HeLa cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay
Antiproliferation activity against human HeLa cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay
[PMID: 32690258]
MCF-10A IC50
> 100 μM
Compound: TPB15
Cytotoxicity against human MCF10A cells assessed as cell viability incubated for 72 hrs measured by MTT assay
Cytotoxicity against human MCF10A cells assessed as cell viability incubated for 72 hrs measured by MTT assay
[PMID: 32690258]
MCF7 IC50
61.5 μM
Compound: TPB15
Antiproliferation activity against human MCF7 cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay
Antiproliferation activity against human MCF7 cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay
[PMID: 32690258]
MDA-MB-231 IC50
29.5 μM
Compound: TPB15
Antiproliferation activity against human MDA-MB-231 cells assessed as reduction in cell viability incubated for 72 hrs measured after 4 hrs by MTT assay
Antiproliferation activity against human MDA-MB-231 cells assessed as reduction in cell viability incubated for 72 hrs measured after 4 hrs by MTT assay
[PMID: 32690258]
MDA-MB-468 IC50
28.6 μM
Compound: TPB15
Antiproliferation activity against human MDA-MB-468 cells assessed as reduction in cell viability incubated for 72 hr by MTT assay
Antiproliferation activity against human MDA-MB-468 cells assessed as reduction in cell viability incubated for 72 hr by MTT assay
[PMID: 32690258]
T47D IC50
42.3 μM
Compound: TPB15
Antiproliferation activity against human T47D cells assessed as reduction in cell viability incubated for 72 hr by MTT assay
Antiproliferation activity against human T47D cells assessed as reduction in cell viability incubated for 72 hr by MTT assay
[PMID: 32690258]
U-251 IC50
85.2 μM
Compound: TPB15
Antiproliferation activity against human U251 cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay
Antiproliferation activity against human U251 cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay
[PMID: 32690258]
分子量

453.11

Formula

C18H9Cl4N5O
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

TPB15 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

TPB152170347-69-8TPB 15TPB-15HedgehogSmoGliApoptosisSmoothenedMDA-MB-468 cells,Hedgehog pathwaysmoothened inhibitortriple-negative breast cancergliomaanti-tumor activityInhibitorinhibitorinhibit

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