2. Metabolic Enzyme/Protease
  3. Phosphodiesterase (PDE)
  4. TPN729

TPN729 是一种选择性 phosphodiesterase type 5 (PDE5) 抑制剂，IC50 值为 2.28 nM。TPN729 影响勃起功能，可用于勃起功能障碍的研究。

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TPN729 Chemical Structure

TPN729 Chemical Structure

CAS No. : 936951-20-1

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规格 是否有货
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100 mg   询价  
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TPN729 的其他形式现货产品:

Customer Review

Other Forms of TPN729:

TPN729 相关抗体

Top Publications Citing Use of Products

查看 Phosphodiesterase (PDE) 亚型特异性产品:

查看所有亚型
PDE1 PDE2 PDE3 PDE4 PDE5 PDE6 PDE7 PDE9 PDE10 PDE11 PDE12 PDE8 Autotaxin

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

TPN729 is a selective phosphodiesterase type 5 (PDE5) inhibitor with an IC50 value of 2.28 nM. TPN729 affects erectile function and it can be used for the research of erectile dysfunction[1].

IC50 & Target

PDE5

2.28 nM (IC50)

PDE6

45.2 nM (IC50)

PDE1

566 nM (IC50)

PDE4

834 nM (IC50)

PDE11

6090 nM (IC50)

体内研究
(In Vivo)

TPN729 (1.25，2.5，5.0 mg/kg；1 次) 在所有时间点 5.0 mg/kg 剂量增加海绵内压/血压比值 (ICP/BP)，在 2.5 mg/kg 剂量下 75，90，105 和 120 分钟时增加海绵内压/血压比[1]。
TPN729 (5.0 μg/kg；静脉注射，1 次) 显著升高公比格犬的海绵内压和海绵内压/血压比[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Male Sprague-Dawley rats with corpora cavernosa complete exposure[1]
Dosage: 1.25, 2.5 and 5.0 mg/kg
Administration: Intraduodenal (i.d.) injection; 1.25, 2.5 and 5.0 mg/kg, once
Result: Dose-dependently increased the maximum intracavernous pressure (ICP) and ICP/blood pressure (BP).
分子量

516.66

Formula

C25H36N6O4S
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

TPN729 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

TPN729936951-20-1TPN 729TPN-729Phosphodiesterase (PDE)selectiveICPICP/BPdogratInhibitorinhibitorinhibit

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产品名称：
TPN729
目录号：
HY-116808
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