2. Neuronal Signaling
  3. Monoamine Oxidase
  4. Tranylcypromine

Tranylcypromine (SKF 385) 是一种有效的单胺氧化酶 (monoamine oxidase) 抑制剂。

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Tranylcypromine Chemical Structure

Tranylcypromine Chemical Structure

CAS No. : 155-09-9

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Tranylcypromine 的其他形式现货产品:

Tranylcypromine 相关抗体

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  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Tranylcypromine (SKF 385) is a potent monoamine oxidase (MAO) inhibitor[1].

细胞效力
(Cellular Effect)
Cell Line Type Value Description References
A549 GI50
1108 μM
Compound: PCPA
Growth inhibition of human A549 cells after 72 hrs by Alamarblue assay
Growth inhibition of human A549 cells after 72 hrs by Alamarblue assay
[PMID: 29331452]
B16-F10 IC50
> 64 μM
Compound: TCP
Cytotoxicity against mouse B16-F10 cells assessed as reduction in cell viability after 48 hrs by MTT assay
Cytotoxicity against mouse B16-F10 cells assessed as reduction in cell viability after 48 hrs by MTT assay
[PMID: 31881456]
BGC-823 IC50
> 50 μM
Compound: TCP
Antiproliferative activity against human BGC-823 cells assessed as cell growth inhibition measured after 72 hrs by MTT assay
Antiproliferative activity against human BGC-823 cells assessed as cell growth inhibition measured after 72 hrs by MTT assay
[PMID: 34416665]
CHO-K1 EC50
1510 nM
Compound: 46
Agonist activity at human trace amine associated receptor 1 expressed in RD-HGA16 CHO-K1 cells coexpressed with Galpha16 protein assessed as internal calcium mobilization by calcium 3 assay
Agonist activity at human trace amine associated receptor 1 expressed in RD-HGA16 CHO-K1 cells coexpressed with Galpha16 protein assessed as internal calcium mobilization by calcium 3 assay
[PMID: 18602830]
ECa-109 cell line IC50
> 64 μM
Compound: TCP
Cytotoxicity against human EC-109 cells assessed as reduction in cell viability after 48 hrs by MTT assay
Cytotoxicity against human EC-109 cells assessed as reduction in cell viability after 48 hrs by MTT assay
[PMID: 31881456]
GES1 IC50
> 50 μM
Compound: TCP
Cytotoxicity against human GES1 cells assessed as cell growth inhibition measured after 72 hrs by MTT assay
Cytotoxicity against human GES1 cells assessed as cell growth inhibition measured after 72 hrs by MTT assay
[PMID: 34416665]
HEK293 GI50
> 500 μM
Compound: PCPA
Growth inhibition of human HEK293 cells after 48 hrs by MTT assay
Growth inhibition of human HEK293 cells after 48 hrs by MTT assay
[PMID: 21227703]
HeLa GI50
> 500 μM
Compound: PCPA
Growth inhibition of human HeLa cells after 48 hrs by MTT assay
Growth inhibition of human HeLa cells after 48 hrs by MTT assay
[PMID: 21227703]
LNCaP IC50
> 100000 μM
Compound: (+)-tranylcypromine
Growth inhibition of human LNCAP cells after 6 days
Growth inhibition of human LNCAP cells after 6 days
[PMID: 21382717]
MCF7 IC50
> 100 μM
Compound: 1; PCPA
Antiproliferative activity against human MCF7 cells assessed as reduction in cell viability after 72 hrs by MTT assay
Antiproliferative activity against human MCF7 cells assessed as reduction in cell viability after 72 hrs by MTT assay
[PMID: 32283297]
MCF7 IC50
> 50 μM
Compound: TCP
Antiproliferative activity against human MCF7 cells assessed as cell growth inhibition measured after 72 hrs by MTT assay
Antiproliferative activity against human MCF7 cells assessed as cell growth inhibition measured after 72 hrs by MTT assay
[PMID: 34416665]
MCF7 IC50
2518.9 μM
Compound: Tranylcypromine
Cytotoxic activity against human MCF7 cells after 24 hrs by MTT assay
Cytotoxic activity against human MCF7 cells after 24 hrs by MTT assay
[PMID: 29496367]
MGC-803 IC50
> 50 μM
Compound: TCP
Antiproliferative activity against human MGC-803 cells assessed as cell growth inhibition measured after 72 hrs by MTT assay
Antiproliferative activity against human MGC-803 cells assessed as cell growth inhibition measured after 72 hrs by MTT assay
[PMID: 34416665]
MGC-803 IC50
> 64 μM
Compound: TCP
Cytotoxicity against human MGC-803 cells assessed as reduction in cell viability after 48 hrs by MTT assay
Cytotoxicity against human MGC-803 cells assessed as reduction in cell viability after 48 hrs by MTT assay
[PMID: 31881456]
MV4-11 IC50
> 100 μM
Compound: 1; TCP
Antiproliferative activity against human MV4-11 cells after 168 hrs by MTS assay
Antiproliferative activity against human MV4-11 cells after 168 hrs by MTS assay
[PMID: 30713023]
NCI-H1975 IC50
> 50 μM
Compound: TCP
Antiproliferative activity against human NCI-H1975 cells assessed as cell growth inhibition measured after 72 hrs by MTT assay
Antiproliferative activity against human NCI-H1975 cells assessed as cell growth inhibition measured after 72 hrs by MTT assay
[PMID: 34416665]
NCI-H460 IC50
> 50 μM
Compound: TCP
Antiproliferative activity against human NCI-H460 cells assessed as cell growth inhibition measured after 72 hrs by MTT assay
Antiproliferative activity against human NCI-H460 cells assessed as cell growth inhibition measured after 72 hrs by MTT assay
[PMID: 34416665]
PC-3 IC50
> 64 μM
Compound: TCP
Cytotoxicity against human PC-3 cells assessed as reduction in cell viability after 48 hrs by MTT assay
Cytotoxicity against human PC-3 cells assessed as reduction in cell viability after 48 hrs by MTT assay
[PMID: 31881456]
SH-SY5Y GI50
500 μM
Compound: PCPA
Growth inhibition of human SH-SY5Y cells after 48 hrs by MTT assay
Growth inhibition of human SH-SY5Y cells after 48 hrs by MTT assay
[PMID: 21227703]
体内研究
(In Vivo)

rel-Tranylcypromine (SKF 385) (0.1 to 3.0 mg/kg; intravenous injection; mongrel dogs, weighing 5-10 kg) elevates the blood pressure. The extent and duration of the rise of blood pressure by the drug depended on the dose administered. When the administration of rel-Tranylcypromine is repeated again and again, the depressor response of the animal to rel-Tranylcypromine is usually obtained[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
Clinical Trial
分子量

133.19

Formula

C9H11N
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Tranylcypromine 相关分类

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Tranylcypromine155-09-9SKF 385SKF385SKF-385Monoamine OxidaseMAOblood pressuredepressorsympathomimetic effectsInhibitorinhibitorinhibit

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