TRK-IN-28

目录号: HY-163366: FAQs
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摩尔计算器

TRK-IN-28 (compound 30f) 是一种 TRK 抑制剂，对 TRK^WT、TRK^G595R 和TRK^G667C的 IC₅₀ 值分别为 0.55 nM、25.1 nM 和 5.4 nM。TRK-IN-2 抑制 Ba/F3 - ETV6 -TRKA^WT、Ba/F3-ETV6-TRKB^WT、Ba/F3-LMNA-TRK^G595R 和 Ba/F3-LMNA-TRKA^G667C 细胞的增殖，IC₅₀ 值分别为 9.5、3.7、205.0 和 48.3 nM。

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TRK-IN-28 Chemical Structure

CAS No. : 2991504-43-7

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TRK-IN-28 相关抗体

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TrkA TrkB TrkC Trk

生物活性

实验参考方法

参考文献

生物活性

TRK-IN-28 (compound 30f) is a TRK inhibitor with the IC₅₀ values of 0.55 nM, 25.1 nM and 5.4 nM against TRK^WT, TRK^G595R and TRK^G667C, respectively. TRK-IN-2 shows antiproliferative activity with IC₅₀ values of 9.5, 3.7, 205.0 and 48.3 nM against Ba/F3-ETV6-TRKA^WT, Ba/F3-ETV6-TRKB^WT, Ba/F3-LMNA-TRK^G595R and Ba/F3-LMNA-TRKA^G667C, respectively^[1].

分子量

485.53

Formula
C₂₇H₂₅F₂N₇

CAS 号
2991504-43-7

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

参考文献

[1]. Xu Y, et al. Design, synthesis and evaluate of indazolylaminoquinazoline derivatives as potent Tropomyosin receptor kinase (TRK) inhibitors. Bioorg Med Chem. 2024;99:117608. [Content Brief]

Cell Assay

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

参考文献

[1]. Xu Y, et al. Design, synthesis and evaluate of indazolylaminoquinazoline derivatives as potent Tropomyosin receptor kinase (TRK) inhibitors. Bioorg Med Chem. 2024;99:117608. [Content Brief]

[1]. Xu Y, et al. Design, synthesis and evaluate of indazolylaminoquinazoline derivatives as potent Tropomyosin receptor kinase (TRK) inhibitors. Bioorg Med Chem. 2024;99:117608.

TRK-IN-28 相关分类

Cancer

肿瘤靶向治疗肿瘤代谢与转移

Neuronal Signaling Protein Tyrosine Kinase/RTK

Trk Receptor

摩尔计算器

稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量浓度体积分子量 *

= × ×

The dilution calculator equation

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

浓度 _(start) × 体积 _(start) = 浓度 _(final) × 体积 _(final)

× = ×

C1 V1 C2 V2

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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Keywords:

TRK-IN-282991504-43-7Trk ReceptorTropomyosin related kinase receptorantiproliferativeBa/F3-ETV6-TRKAWT、Ba/F3-ETV6-TRKBWT、Ba/F3-LMNA-TRKG595R、Ba/F3-LMNA-TRKAG667CInhibitorinhibitorinhibit

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生物活性	TRK-IN-28 (compound 30f) is a TRK inhibitor with the IC₅₀ values of 0.55 nM, 25.1 nM and 5.4 nM against TRK^WT, TRK^G595R and TRK^G667C, respectively. TRK-IN-2 shows antiproliferative activity with IC₅₀ values of 9.5, 3.7, 205.0 and 48.3 nM against Ba/F3-ETV6-TRKA^WT, Ba/F3-ETV6-TRKB^WT, Ba/F3-LMNA-TRK^G595R and Ba/F3-LMNA-TRKA^G667C, respectively^[1].
分子量	485.53
Formula	C₂₇H₂₅F₂N₇
CAS 号	2991504-43-7
运输条件	Room temperature in continental US; may vary elsewhere.
储存方式	Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献	[1]. Xu Y, et al. Design, synthesis and evaluate of indazolylaminoquinazoline derivatives as potent Tropomyosin receptor kinase (TRK) inhibitors. Bioorg Med Chem. 2024;99:117608. [Content Brief]

Cell Assay	MCE has not independently confirmed the accuracy of these methods. They are for reference only.
参考文献	[1]. Xu Y, et al. Design, synthesis and evaluate of indazolylaminoquinazoline derivatives as potent Tropomyosin receptor kinase (TRK) inhibitors. Bioorg Med Chem. 2024;99:117608. [Content Brief]

浓度 _(start)	×	体积 _(start)	=	浓度 _(final)	×	体积 _(final)
	×		=		×
C1		V1		C2		V2

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MedChemExpress (MCE) 只为有资质的科研机构、医药企业基于科学研究或药证申报的用途提供医药研发服务，不为任何个人或者非科研性质的、非用于药证申报使用等其他用途提供服务。

站点地图隐私声明

沪ICP备15051369号-4

上海工商

沪公网安备31011502019417

沪(浦)应急管危经许[2021]201709(QFYS)

营业执照（三证合一）

TRK-IN-28

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TRK-IN-28 相关抗体

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查看 Trk Receptor 亚型特异性产品:

生物活性

实验参考方法

参考文献

TRK-IN-28 相关分类

摩尔计算器

稀释计算器

The molarity calculator equation

The dilution calculator equation

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