2. Vitamin D Related/Nuclear Receptor
  3. Thyroid Hormone Receptor
  4. TRβ agonist 1

TRβ agonist 1 是一种具有选择性和对突变敏感的甲状腺激素受体 β (TRβ) 激动剂，EC50 为 21 nM。TRβ agonist 1 可用于血脂异常、非酒精性脂肪性肝炎 (NASH) 和甲状腺激素抵抗 (RTH) 的研究。

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TRβ agonist 1 Chemical Structure

TRβ agonist 1 Chemical Structure

CAS No. : 2770681-85-9

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TRβ agonist 1 相关抗体

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  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

TRβ agonist 1 is a selective and mutation-sensitive thyroid hormone receptor β (TRβ) agonist, with an EC50 value of 21 nM. TRβ agonist 1 can be used for researching dyslipidemia, nonalcoholic steatohepatitis (NASH), and resistance to thyroid hormone (RTH)[1].

IC50 & Target

EC50: 21.0 nM [TRβ (WT)], 1344.0 nM [TRβ (H435R)][1]
体外研究
(In Vitro)

TRβ agonist 1 (compound 16g) (1, 3, 10 μM; 24 hours) reduces lipid accumulation and cholesterol levels by triglyceride (TG) and total cholesterol (TC) analyses in HepG2 cells and primary mouse hepatocytes; also reduces the total lipid accumulation at 10 μM[1].
TRβ agonist 1 (10 μM; 24 hours) induces a significant enhancement of the p-AMPK/AMPK ratio, the p-ACC/ACC ratio, and CPT1 levels[1].
TRβ agonist 1 (0.01, 0.1, 1 and 10 μM; 24 hours) does not display significant cellular toxicity on multiple cell lines (HepG2, 22Rv1, A549, MCF7, MDA-MB-231, HFL-1, and BxPC-3) at concentrations up to 10 μM[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

TRβ agonist 1 相关抗体:
分子量

548.52

Formula

C29H25FN2O8
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

TRβ agonist 1 相关分类

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质量   浓度   体积   分子量 *
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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

TRβ agonist 12770681-85-9TRβ agonist1TRβ agonist-1Thyroid Hormone ReceptorTHRTriglycerideCholesterolHepG2Lipid accumulationInhibitorinhibitorinhibit

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TRβ agonist 1
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