2. Autophagy PROTAC
  3. AUTACs Mitophagy
  4. TSPO Ligand-Linker Conjugates 1

TSPO Ligand-Linker Conjugates 1 

目录号: HY-147225
产品使用指南

摩尔计算器

TSPO Ligand-Linker Conjugates 1 包含转运蛋白 (TSPO) 的配体和连接子，可用来合成靶向线粒体的自噬靶向嵌合体 (AUTAC)。AUTAC 可与线粒体外膜 (OMM) 上的 TSPO 结合，并通过线粒体自噬 (mitophagy) 降解受损的线粒体和蛋白质，并提高线粒体活性。TSPO Ligand-Linker Conjugates 1 可用于线粒体功能紊乱的相关研究，如神经退行性疾病、癌症和糖尿病。

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TSPO Ligand-Linker Conjugates 1 Chemical Structure

TSPO Ligand-Linker Conjugates 1 Chemical Structure

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TSPO Ligand-Linker Conjugates 1 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

TSPO Ligand-Linker Conjugates 1 contains a ligand for translocator protein (TSPO) and a linker, which is used for the synthesis of mitochondria-targeting autophagy-targeting chimera (AUTAC). AUTAC can bind the TSPO on the outer mitochondrial membrane (OMM) of mitochondria and degrades impaired mitochondria and proteins via mitophagy, and improves mitochondrial activity. TSPO Ligand-Linker Conjugates 1 can be used in mitochondrial dysfunction related research, including neurodegenerative diseases, cancer, and diabetes[1].

体外研究
(In Vitro)

AUTAC (0-100 μM, 24 h) realizes targeted degradation of endogenous proteins in HeLa cells (MetAP2, FKBP12)[1].
AUTAC (10 μM, 10 h) reverses mitochondrial dysfunction via K63-Linked ubiquitination in HeLa cells[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

TSPO Ligand-Linker Conjugates 1 相关抗体:

Western Blot Analysis[1]

Cell Line: HeLa cells
Concentration: 0.1, 1, 10, 100 μM
Incubation Time: 24 h
Result: AUTAC degraded endogenous proteins (MetAP2, FKBP12).
分子量

673.86

Formula

C32H55N3O10S
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

TSPO Ligand-Linker Conjugates 1 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

TSPO Ligand-Linker Conjugates 1AUTACsMitophagyAutophagy-targeting chimerasMitochondrial AutophagyautophagylinkerTSPOOMMmitochondriacytosolicmitophagyInhibitorinhibitorinhibit

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