2. Cell Cycle/DNA Damage Cytoskeleton
  3. Microtubule/Tubulin
  4. Tubulin inhibitor 26

Tubulin inhibitor 26 (compound 3c) 是一种有效的 tubulin 抑制剂。Tubulin inhibitor 26 是一种吲唑衍生物化合物。Tubulin inhibitor 26 对 HepG2、HCT116、SW620、HT29 和 A549 癌细胞系表现出显着的低纳摩尔效力。Tubulin inhibitor 26 将肿瘤细胞阻滞在G2/M 期并诱导细胞凋亡。Tubulin inhibitor 26 在体内抑制肿瘤生长而不影响小鼠体重。

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Tubulin inhibitor 26 Chemical Structure

Tubulin inhibitor 26 Chemical Structure

CAS No. : 2379241-70-8

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Tubulin inhibitor 26 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Tubulin inhibitor 26 (compound 3c) is a potent inhibitor of tubulin. Tubulin inhibitor 26 is an indazole derivative compound. Tubulin inhibitor 26 shows noteworthy low nanomolar potency against HepG2, HCT116, SW620, HT29 and A549 cancer cell lines. Tubulin inhibitor 26 arrests tumor cell in G2/M phase and induced cell apoptosis. Tubulin inhibitor 26 suppresses tumor growth in vivo without affecting the mice body weight[1].

细胞效力
(Cellular Effect)
Cell Line Type Value Description References
A549 GI50
0.033 μM
Compound: 3c
Antiproliferative activity against human A549 cells assessed as cell viability after 72 hrs by MTT assay
Antiproliferative activity against human A549 cells assessed as cell viability after 72 hrs by MTT assay
[PMID: 31865012]
HCT-116 GI50
0.015 μM
Compound: 3c
Antiproliferative activity against human HCT-116 cells assessed as cell viability after 72 hrs by MTT assay
Antiproliferative activity against human HCT-116 cells assessed as cell viability after 72 hrs by MTT assay
[PMID: 31865012]
HepG2 GI50
0.027 μM
Compound: 3c
Antiproliferative activity against human HepG2 cells assessed as cell viability after 72 hrs by MTT assay
Antiproliferative activity against human HepG2 cells assessed as cell viability after 72 hrs by MTT assay
[PMID: 31865012]
HT-29 GI50
0.031 μM
Compound: 3c
Antiproliferative activity against human HT-29 cells assessed as cell viability after 72 hrs by MTT assay
Antiproliferative activity against human HT-29 cells assessed as cell viability after 72 hrs by MTT assay
[PMID: 31865012]
HUVEC GI50
> 25 μM
Compound: 3c
Cytotoxicity against HUVEC assessed as cell viability after 72 hrs by MTT assay
Cytotoxicity against HUVEC assessed as cell viability after 72 hrs by MTT assay
[PMID: 31865012]
SW-620 GI50
0.008 μM
Compound: 3c
Antiproliferative activity against human SW-620 cells assessed as cell viability after 72 hrs by MTT assay
Antiproliferative activity against human SW-620 cells assessed as cell viability after 72 hrs by MTT assay
[PMID: 31865012]
分子量

313.35

Formula

C17H19N3O3
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Tubulin inhibitor 26 相关分类

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Tubulin inhibitor 262379241-70-8Tubulin inhibitor26Tubulin inhibitor-26Microtubule/Tubulinindazole derivativecancerG2/M phaseapoptosisbody weightInhibitorinhibitorinhibit

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