2. Cell Cycle/DNA Damage Cytoskeleton
  3. Microtubule/Tubulin
  4. Tubulin inhibitor 40

Tubulin inhibitor 40（compound 45）是一种 Tubulin 抑制剂，IC50 值是1.2 μM。Tubulin inhibitor 40 对癌细胞具有选择性的细胞毒性。Tubulin inhibitor 40 具有抗肿瘤活性。

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Tubulin inhibitor 40 Chemical Structure

Tubulin inhibitor 40 Chemical Structure

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Tubulin inhibitor 40 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Tubulin inhibitor 40 (compound 45) is a tubulin inhibitor with IC50 of 1.2 μM. Tubulin inhibitor 40 shows selective cytotoxicity towards cancer cells. Tubulin inhibitor 40 processes antitumor activity [1].

IC50 & Target

0.005 μM (Tubulin, A549), 0.008 μM (Tubulin, VA13), 0.009 μM (Tubulin, MCF7’), 0.008 μM (Tubulin, HEK293T)[1]
体外研究
(In Vitro)

Tubulin inhibitor 40 对 A549，VA13，MCF7’ 和 HEK293T 细胞系具有细胞毒性，IC50 值分别为 0.005 μM，0.008 μM，0.009 μM 和 0.008 μM[1]。
Tubulin inhibitor 40 抑制微管蛋白（tubulin）聚合，IC50 值是 1.2 μM [1]。
Tubulin inhibitor 40 （1-25 μM, 24 h）可引起 A549 中细胞形态和微管蛋白聚合的变化[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Tubulin inhibitor 40 相关抗体:

Cell Cytotoxicity Assay[1]

Cell Line: A549, VA13, MCF7’, HEK293T
Concentration: a range of concentrations from a few nM to 100 μM
Incubation Time: 72 h
Result: Showed cytotoxicity towards cell lines A549, VA13, MCF7’ and HEK293T.
体内研究
(In Vivo)

Tubulin inhibitor 40（静脉注射，20 mg/kg，5 天） 具有抗肿瘤活性[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: antitumor efficacy in murine L1210 and P388 leukemia in BALB/c nude mice[1]
Dosage: 20 mg/kg, i.v., 5 days
Administration: intravenous injection
Result: Showed T/C values of 233% and 324% for P388 and L1210 leukemia.
Animal Model: Antitumor Efficacy in Human Cancer Xenografts.SW620 in BALB/c nude mice[1]
Dosage: 20 mg/kg, i.v., 5 days
Administration: i.v. .intravenous injection
Result: Reduced tumor growth by 74%.
分子量

356.37

Formula

C19H20N2O5
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Tubulin inhibitor 40 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Tubulin inhibitor 40Tubulin inhibitor40Tubulin inhibitor-40Microtubule/TubulinantitumortubulinA549VA13MCF7’HEK293TBALB/c nude miceInhibitorinhibitorinhibit

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目录号：
HY-163195
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