2. Cell Cycle/DNA Damage Cytoskeleton Apoptosis
  3. Microtubule/Tubulin Apoptosis
  4. Tubulin polymerization-IN-24

Tubulin aggregation-IN-24 (compound HMBA) 是一种有效的tubulin aggregation 抑制剂。Tubulin aggregation-IN-24 抑制 MCF-7 细胞增殖。Tubulin aggregation-IN-24 诱导细胞凋亡 (apoptosis) 和细胞周期停滞在 G2/M 期。Tubulin aggregation-IN-24 增加 GTP 水解速率并抑制微管组装。

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Tubulin polymerization-IN-24 Chemical Structure

Tubulin polymerization-IN-24 Chemical Structure

CAS No. : 564468-51-5

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规格 价格 是否有货 数量
10 mg ￥2549
3 - 4 周
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Tubulin polymerization-IN-24 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Tubulin polymerization-IN-24 (compound HMBA) is a potent tubulin polymerization inhibitor. Tubulin polymerization-IN-24 inhibits MCF-7 cells proliferation. Tubulin polymerization-IN-24 induces apoptosis and cell cycle arrest at G2/M phase. Tubulin polymerization-IN-24 increase the GTP hydrolysis rate and inhibits microtubule assembly[1].

体外研究
(In Vitro)

Tubulin polymerization-IN-24 (compound HMBA) inhibits the assembly of purified tubulin (MAPs-free) in a concentration dependent manner[1].
Tubulin polymerization-IN-24 (0-100 nM) inhibits MCF-7 proliferation in a concentration dependent fashion with an IC50 value of 47 nM[1].
Tubulin polymerization-IN-24 competitively inhibits colchicine binding to tubulin with a Ki value of 3.6 μM[1].
Tubulin polymerization-IN-24 inhibits the progression of MCF-7 cells in mitosis and induces apoptotic cell death involving p53 pathway[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Tubulin polymerization-IN-24 相关抗体:
分子量

328.36

Formula

C22H16O3
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Tubulin polymerization-IN-24 相关分类

  • 摩尔计算器

  • 稀释计算器

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  • Do most proteins show cross-species activity?

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Keywords:

Tubulin polymerization-IN-24564468-51-5Microtubule/TubulinApoptosisanticanceranti-proliferationMCF-7 cellsG2/M phaseapoptosisGTP hydrolysismicrotubule assemblyp53Inhibitorinhibitorinhibit

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