2. Cell Cycle/DNA Damage Cytoskeleton
  3. Microtubule/Tubulin
  4. Tubulin polymerization-IN-39

Tubulin polymerization-IN-39 是一种微管蛋白聚合 (tubulin polymerization) 抑制剂 (IC50: 4.9 μM)。Tubulin polymerization-IN-39 占据秋水仙碱结合位点。Tubulin polymerization-IN-39 抑制癌细胞增殖。

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Tubulin polymerization-IN-39 Chemical Structure

Tubulin polymerization-IN-39 Chemical Structure

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Tubulin polymerization-IN-39 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Tubulin polymerization-IN-39 is a tubulin polymerization inhibitor (IC50: 4.9 μM). Tubulin polymerization-IN-39 occupies the colchicine-binding site. Tubulin polymerization-IN-39 inhibits cancer cell proliferation[1].

体外研究
(In Vitro)

Tubulin polymerization-IN-39 (compound 4k) 对 HeLa、HCT116、A549 和 T47D 细胞具有抗增殖活性，IC50 值分别为 0.31、1.28、3.99 和 10.32 μM[ 1].
Tubulin polymerization-IN-39 (0.15-0.6 μM, 24 h) 增加 G2/M 期 HeLa 细胞的百分比[1]。
Tubulin polymerization-IN-39 (0.15-0.6 μM, 24 h) 通过增加裂解的 PARP 诱导 HeLa 细胞凋亡[1] 。
Tubulin polymerization-IN-39 (0.2-0.8 μM, 24 h) 抑制 HUVEC 的迁移[1]。
Tubulin polymerization-IN-39 (10 μM) 抑制 78% 的微管蛋白聚合[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Tubulin polymerization-IN-39 相关抗体:

Cell Viability Assay[1]

Cell Line: HeLa cells
Concentration: 0.15, 0.3, 0.6 μM
Incubation Time: 24 h
Result: Increased cyclin B1 protein level and cleaved PARP.
Decreased p-cdc2 (the inactive form of cdc2).

Cell Migration Assay [1]

Cell Line: HUVEC
Concentration: 0.2, 0.4, 0.8 μM
Incubation Time: 24 h
Result: Dose-dependently inhibited HUVEC migration.
Prevented HUVEC motility and migration (wound healing assay).
分子量

423.42

Formula

C21H21N5O5
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Tubulin polymerization-IN-39 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Tubulin polymerization-IN-39Microtubule/TubulinTubulin polymerizationHUVECHeLatube formationcancerInhibitorinhibitorinhibit

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HY-151982
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