2. Cell Cycle/DNA Damage Cytoskeleton
  3. Microtubule/Tubulin
  4. Tubulin polymerization-IN-44

Tubulin polymerization-IN-44 (7w) 是一种强有效的微管蛋白抑制剂，IC50 值为0.21 μM。Tubulin polymerization-IN-44通过触发G2/M 期阻滞，引起癌细胞凋亡 (apoptosis)，可用于肿瘤领域的研究。

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Tubulin polymerization-IN-44 Chemical Structure

Tubulin polymerization-IN-44 Chemical Structure

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Tubulin polymerization-IN-44 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Tubulinpolymer-in-44 (compound 7w) is a strong and effective Tubulin inhibitor, with an IC50 value of 0.21 μM. Tubulinpolymer-in-44 induces apoptosis by arresting G2/M phase, which can be used for cancer research.

IC50 & Target

IC50: 0.21 μM (Tubulin)[1]
体外研究
(In Vitro)

Tubulin polymerization-IN-44 (0.42 μM, 24 h- 48 h ) 有良好的抑制SGC-7910 细胞增殖活性IC50值为0.21 μM。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Tubulin polymerization-IN-44 相关抗体:

Cell Cycle Analysis

Cell Line: SGC-7901 cells[1]
Concentration: 0.42 μM
Incubation Time: 24 h- 48 h
Result: Extended up the percentage of cells in G2/M phase from 10% to 42% (24 h) after treatment.
Induced cell apoptosis at about 48 h.
体内研究
(In Vivo)

Tubulin Polymers-in-44（5-20 mg/kg，每隔一天）可抑制乳腺癌 4T1 细胞小鼠模型的肿瘤生长，且不会减少体重减轻。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Balb/c female mice (mouse breast cancer 4T1 cells )[1]
Dosage: 5, 10, and 20 mg/kg; every other day
Administration: intravenous injection (i.c.) ;12-day.
Result: Inhibited tumor growth with the rate of 49.2%, 58.1% and 84.0% at the dose of 5, 10 and 20 mg/kg ;
Did not cause a decrease in animal body weight even at the high dose (20 mg/kg).
分子量

436.31

Formula

C19H15Cl2N3O3S
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Tubulin polymerization-IN-44 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Tubulin polymerization-IN-44Microtubule/TubulinCell apoptosisSGC-7901 cellsBreast cancer 4T1Tubulin inhibitor,Inhibitorinhibitorinhibit

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