2. Cell Cycle/DNA Damage Cytoskeleton Apoptosis Epigenetics
  3. Microtubule/Tubulin Apoptosis PARP Caspase
  4. Tubulin polymerization-IN-68

Tubulin polymerization-IN-68 (compound 32) 是微管蛋白抑制剂，可以抑制微管蛋白聚合并破坏细胞微管网络。Tubulin polymerization-IN-68 可以上调 PARP-1 和 caspase-3 表达并诱导细胞凋亡，具有抗癌活性。Tubulin polymerization-IN-68 能够有效抑制 HepG2 (IC50=93 nM)，并通过灌胃给药显著抑制裸鼠的 HepG2 异种移植瘤的生长。

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Tubulin polymerization-IN-68 Chemical Structure

Tubulin polymerization-IN-68 Chemical Structure

CAS No. : 2924156-96-5

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Tubulin polymerization-IN-68 相关抗体

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PARP PARP1 PARP2 PARP3 PARP4 TNKS1/PARP5A TNKS2/PARP5B PARP7 PARP10 PARP14 PARP15 PARP12 PARP16

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  • 生物活性

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生物活性

Tubulin polymerization-IN-68 (compound 32) is a tubulin inhibitor that can inhibit tubulin polymerization and destroy the cellular microtubule network. Tubulin polymerization-IN-68 can upregulate the expression of PARP-1 and caspase-3 and induce cell apoptosis, and has anticancer activity. Tubulin polymerization-IN-68 can effectively inhibit HepG2 (IC50=93 nM) and significantly inhibit the growth of HepG2 xenograft tumors in nude mice by oral administration[1].

IC50 & Target

PARP-1[1]
分子量

263.29

Formula

C16H13N3O
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Tubulin polymerization-IN-68 相关分类

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  • Do most proteins show cross-species activity?

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Keywords:

Tubulin polymerization-IN-682924156-96-5Microtubule/TubulinApoptosisPARPCaspasepoly ADP ribose polymeraseInhibitorinhibitorinhibit

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