2. Antibody-drug Conjugate/ADC Related Cytoskeleton Cell Cycle/DNA Damage
  3. ADC Cytotoxin Microtubule/Tubulin
  4. Tubulysin H

Tubulysin H  (Synonyms: 微管蛋白抑制剂 H)

目录号: HY-N7051
产品使用指南

摩尔计算器

Tubulysin H 是具有高细胞毒性的抗微管毒素 (anti-microtubule toxins)，作为 ADC 细胞毒素 (ADC Cytotoxin) 合成 ADC。Tubulysin H 能够从粘细菌 Archangium geophyra 和 Angiococcus disciformis 中分离得到。Tubulysin H 在哺乳动物细胞中显示出极其有效的细胞毒活性，包括多药耐药细胞系，IC50 值在较低的纳摩尔范围内。Tubulysin H 可抑制微管蛋白 (Microtubule/Tubulin) 聚合并导致细胞周期停滞和凋亡 (apoptosis)。

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Tubulysin H Chemical Structure

Tubulysin H Chemical Structure

CAS No. : 799822-09-6

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Tubulysin H 相关抗体

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  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Tubulysin H is a highly cytotoxic anti-microtubule toxin (anti-microtubule toxins) that is synthesized as an ADC cytotoxin (ADC Cytotoxin). Tubulysin H can be isolated from the myxobacteria Archangium geophyra and Angiococcus disciformis. Tubulysin H displays extremely potent cytotoxic activity in mammalian cells, including multidrug-resistant cell lines, with IC50 values in the low nanomolar range. Tubulysin H inhibits microtubule/tubulin polymerization and leads to cell cycle arrest and apoptosis[1][2][3].

分子量

785.99

Formula

C40H59N5O9S
CAS 号
中文名称

微管蛋白抑制剂 H
结构分类
初始来源

Archangium gephyra and Angiococcus disciformis
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Tubulysin H 相关分类

  • 摩尔计算器

  • 稀释计算器

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Tubulysin H799822-09-6微管蛋白抑制剂 HADC CytotoxinMicrotubule/TubulinADC PayloadInhibitorinhibitorinhibit

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