2. Cell Cycle/DNA Damage Anti-infection
  3. DNA/RNA Synthesis Topoisomerase Bacterial
  4. Type II topoisomerase inhibitor 1

Type II topoisomerase inhibitor 1 

目录号: HY-150044
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摩尔计算器

Type II topoisomerase inhibitor 1 是一种有效的、选择性的 E. coli DNA 旋转酶 (DNA gyrase) 抑制剂(IC50: 1.7 nM)，可与 Asp73 残基形成氢键。Type II topoisomerase inhibitor 1 抑制拓扑异构酶 IV (topoisomerase IV) 的活性 (IC50: 0.98 μM)。Type II topoisomerase inhibitor 1 可用于抗菌方面的研究。

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Type II topoisomerase inhibitor 1 Chemical Structure

Type II topoisomerase inhibitor 1 Chemical Structure

CAS No. : 2245691-60-3

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  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Type II topoisomerase inhibitor 1 is a potent and selective E. coli DNA gyrase inhibitor (IC50: 1.7 nM), and forms hydrogen bonds with Asp73 residue. Type II topoisomerase inhibitor 1 inhibits topoisomerase IV activity (IC50: 0.98 μM). Type II topoisomerase inhibitor 1 can be used in the research of antibacterial area[1][2].

IC50 & Target[1]

topoisomerase IV

0.98 μM (IC50)

DNA gyrase

1.7 nM (IC50)

体外研究
(In Vitro)

Type II topoisomerase inhibitor 1 (13 e, 18 h) shows antibacterial activities against E. coli and S. aureus (MIC: 64 and 16 μg/mL, respectively)[1].
Type II topoisomerase inhibitor 1 (50 μM, 48 h) shows an 8.4% inhibition rate for HepG2 cells[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Type II topoisomerase inhibitor 1 相关抗体:

Cell Viability Assay[1]

Cell Line: HepG2 cells
Concentration: 10, 50 μM
Incubation Time: 10, 50 μM
Result: Showed cytoxicity with inhibition rates of 8.4% at 50 μM, 1.5% at 10 μM.
分子量

337.33

Formula

C18H15N3O4
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Type II topoisomerase inhibitor 1 相关分类

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Type II topoisomerase inhibitor 12245691-60-3Type II topoisomerase inhibitor1Type II topoisomerase inhibitor-1DNA/RNA SynthesisTopoisomeraseBacterialE. coliS. aureusDNA gyraseanti-bacterialGHKLATPaseinfectionHepG2 cellsInhibitorinhibitorinhibit

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